MR-Guided Transcranial Focused Ultrasound
MR-Guided Transcranial Focused Ultrasound
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DOI：
10.1007/978-3-319-22536-4_6
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Tanter, Mickael
中科院分区：
文献类型：
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作者：
Aubry, Jean-Francois;Tanter, Mickael
前几章介绍了使用聚焦超声消融组织的能力。它在治疗子宫肌瘤、前列腺癌或肝癌方面产生了各种临床应用。然而，用聚焦超声非侵入性地治疗大脑被认为是遥不可及的近世纪：颅骨保护大脑免受机械损伤，但它也反射和折射超声，使得难以用聚焦超声靶向大脑。幸运的是，最近已经发展了像差校正技术，并且在临床上已经实现了丘脑的热损伤。本章介绍了颅骨的畸变效应以及如何非侵入性地对其进行校正。它还介绍了热消融获得的最新临床结果，并介绍了新的非热方法，可以在未来彻底改变脑治疗。
Previous chapters introduced the ability of using focused ultrasound to ablate tissues. It has led to various clinical applications in the treatment of uterine fibroid, prostate or liver cancers. Nevertheless, treating the brain non-invasively with focused ultrasound has been considered beyond reach for almost a century: The skull bone protects the brain from mechanical injuries, but it also reflects and refracts ultrasound, making it difficult to target the brain with focused ultrasound. Fortunately, aberration correction techniques have been developed recently and thermal lesioning in the thalamus has been achieved clinically. This chapter introduces the aberration effect of the skull bone and how it can be corrected non-invasively. It also presents the latest clinical results obtained with thermal ablation and introduces novel non-thermal approaches that could revolutionize brain therapy in the future.