Au-Catalyzed [2+3] Annulation of Enamides with Propargyl Esters: Total Synthesis of Cephalotaxine and Cephalezomine H
Au-Catalyzed [2+3] Annulation of Enamides with Propargyl Esters: Total Synthesis of Cephalotaxine and Cephalezomine H
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Au 催化 [2 3] 烯酰胺与炔丙酯的环化：头孢噻嗪和头孢唑明 H 的全合成
DOI：
10.1021/acs.orglett.7b01202
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Chun-An Fan
中科院分区：
文献类型：
--
作者：
Xiao-Yan Ma;Man-Tao An;Xian-He Zhao;Ji-Yuan Du;Yu-Hua Deng;Xiang-Zhi Zhang;Chun-An Fan
A novel Au-catalyzed [2 + 3] annulation reaction of enamides with propargyl esters has been developed, providing a new method for expeditious assembly of synthetically useful functionalized 1-azaspiro[4.4]nonane building blocks. Based on this key annulation, strategic installation of the pivotal azaspirocyclic core, followed by constructing the benzazepine unit via Witkop cyclization, led to the divergent total syntheses of cephalotaxine and cephalezomine H.
