Effects of ethanol on cAMP production in murine embryonic palate mesenchymal cells.
Effects of ethanol on cAMP production in murine embryonic palate mesenchymal cells.
复制标题
乙醇对小鼠胚胎腭间充质细胞 cAMP 产生的影响。
DOI：
10.1016/0024-3205(91)90065-j
复制
发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Greene,RM
中科院分区：
文献类型：
--
作者：
Weston,WM;Greene,RM
Ethanol affected the ability of murine embryonic palate mesenchymal (MEPM) cells to produce cAMP in response to hormone treatment. Acute exposure to ethanol resulted in an increase in hormone-stimulated cAMP levels, while chronic ethanol treatment led to decreased sensitivity to hormone. Forskolin-stimulated cAMP levels were decreased by both acute and chronic ethanol treatment, while the cells' response to cholera toxin was unchanged by ethanol treatment. The lack of sensitivity of the cholera toxin response to ethanol suggests that, in contrast to what has been observed in other systems, ethanol does not affect the production or activity of Gαs in MEPM cells. These results suggest a possible explanation for the molecular basis for the craniofacial abnormalities observed in the fetal alcohol syndrome.
