Autophagy: Many paths to the same end
Autophagy: Many paths to the same end
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DOI：
10.1023/b:mcbi.0000041848.57020.57
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发表时间：
2004-08-01
影响因子：
4.3
通讯作者：
Cuervo, AM
中科院分区：
文献类型：
--
作者：
Cuervo, AM
不同的机制导致溶酶体区室中细胞内蛋白质的降解。在特定的细胞条件下，一种或另一种自噬途径的激活在细胞适应环境变化的能力中起着重要作用。每种形式的自噬都有自己的特点，但它也与其他形式的自噬共享共同的步骤和组件。自噬途径的这种相互依赖性赋予溶酶体系统对底物降解的特异性和灵活性。在这篇综述中，我们描述了一些最近的研究结果的分子基础和调节每个不同的自噬途径。我们还讨论了它们相互依赖的功能的细胞后果。自噬系统的功能障碍具有戏剧性的后果，特别是在非分裂的分化细胞中。以心脏为例，我们分析了自噬在衰老和细胞死亡以及不同病理条件下的相关性。
Different mechanisms lead to the degradation of intracellular proteins in the lysosomal compartment. Activation of one autophagic pathway or another, under specific cellular conditions, plays an important role in the ability of the cell to adapt to environmental changes. Each form of autophagy has its own individual characteristics, but it also shares common steps and components with the others. This interdependence of the autophagic pathways confers to the lysosomal system, both specificity and flexibility on substrate degradation. We describe in this review some of the recent findings on the molecular basis and regulation for each of the different autophagic pathways. We also discuss the cellular consequences of their interdependent function. Malfunctioning of the autophagic systems has dramatic consequences, especially in non-dividing differentiated cells. Using the heart as an example of such cells, we analyze the relevance of autophagy in aging and cell death, as well as in different pathological conditions.