Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remission
Electroencephalographic sleep profiles in single-episode and recurrent unipolar forms of major depression: II. Comparison during remission
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DOI：
10.1016/s0006-3223(01)01226-4
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发表时间：
2002-02-01
影响因子：
10.6
通讯作者：
Kupfer, DJ
中科院分区：
文献类型：
--
作者：
Jindal, RD;Thase, ME;Kupfer, DJ
背景资料：先前的研究表明，与单次发作病例相比，复发性抑郁症与更大的生物学紊乱有关。本研究探讨是否观察到的睡眠模式的差异，在复发性和单次发作的抑郁症持续到缓解以下nonpharmacologictreatment.Methods：两组患者（27单次发作[SE]和53复发性单极[RU]）与抑郁症进行睡眠研究之前和之后的非药物治疗。各组在年龄、严重程度和男女比例方面相等。使用多变量协方差分析和/或协方差分析组进行了比较，以检查六组的睡眠measures.Results：观察到的差异之间的SE和RU组在指数发作持续到早期缓解。RU组的睡眠连续性、快速眼动睡眠和慢波睡眠减少的干扰更大，这一发现支持了以下假设：复发性抑郁症与比临床上可比较的SE病例更严重的神经生理学基质相关。尽管这些观察结果与疾病进展模型一致，但复发性情感性疾病与更致命的，不能排除稳定表型。解决这个问题需要进行纵向和家庭研究。生物精神病学2002;51：230-236（C）2002生物精神病学学会。
Background: Previous studies indicate that recurrent forms of depression are associated with greater biological disturbances as compared to single-episode cases. This study examines whether the observed differences in the sleep patterns during recurrent and single-episode depression persist into remission following nonpharmacologic treatment.Methods: Two groups of patients (27 single episode [SE] and 53 recurrent unipolar [RU]) with major depression underwent sleep studies before and after nonpharmacologic treatment. Groups were equated for age, severity, and proportion of men and women. Groups were compared using multivariate analyses of covariance and/or analyses of covariance to examine six sets of sleep measures.Results: The differences observed between the SE and RU groups during the index episode persisted into early remission. The findings of greater disturbances of sleep continuity, rapid eye movement sleep and diminished slow wave sleep in the RU group supports the hypothesis that recurrent depression is associated with a more severe neurophysiological substrate than clinically comparable SE cases.Conclusions: Although these observations are consistent with an illness progression model, the possibility that recurrent affective illness is associated with a more virulent, stable phenotype cannot be ruled out. Resolution of this issue requires longitudinal and family studies. Biol Psychiatry 2002;51:230-236 (C) 2002 Society of Biological Psychiatry.