The serotonin transporter gene variants modulate acute stress-induced hippocampus and dorsomedial prefrontal cortex activity during memory retrieval
The serotonin transporter gene variants modulate acute stress-induced hippocampus and dorsomedial prefrontal cortex activity during memory retrieval
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血清素转运蛋白基因变异在记忆检索过程中调节急性应激诱导的海马和背内侧前额皮质活动
DOI：
10.1002/pchj.297
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发表时间：
2019-07-02
期刊：
影响因子：
1.6
通讯作者：
Wolf，Oliver T.
中科院分区：
文献类型：
--
作者：
Li，Shijia;Tang，Jun;Wolf，Oliver T.
5-羟色胺转运体基因(5-HTTLPR)启动子区的短等位基因(S)与5-羟色胺转运体效率降低以及对应激和精神障碍的易感性增加有关。在本研究中，我们通过重新分析一个小的遗传神经成像数据集，研究了5-HTTLPR如何影响应激下的记忆提取和相关的神经活动。27名健康男性志愿者参加了特里尔社会压力测试(TSST)和各自的控制程序，然后在执行情绪面孔识别任务时，用功能磁共振成像(FMRI)测量了他们的大脑活动。16名受试者为短等位基因携带者(ss/sl携带者)，11名受试者为长等位基因纯合子(11携带者)。在与压力相关的生理变化、记忆表现和大脑活动方面，对不同的基因型组进行了比较。没有发现显著的基因依赖对记忆成绩或皮质醇水平的影响。Ss/sl携带者的收缩压和舒张压显著高于ll携带者，与应激无关。Ss/sl携带者表现出比ll携带者更强烈的应激诱导的神经情绪。我们的fMRI数据显示，与ll携带者相比，ss/sl携带者在应激条件下提取记忆时，左侧海马区的激活明显减弱，背内侧前额叶皮质(DmPFC)的失活明显增强。随后的分析表明，两种基因型的不同海马区激活模式与应激诱导的皮质醇升高有关，而两种基因型的不同dmPFC激活模式与应激诱导的反应时变化有关。因此，我们的结果增加了新的证据，即在急性心理社会应激下，5-羟色胺信号调节记忆提取过程中海马区和dmPFC的神经活动。
The short (s) allele of a polymorphism in the promoter region of the serotonin transporter gene (5‐HTTLPR) is related to reduced serotonin transporter efficiency and an increased vulnerability to stress and mental disorders. In the present study, we investigated how 5‐HTTLPR impacts on memory retrieval under stress and related neural activity by reanalyzing a small genetic neuroimaging data set. Twenty‐seven healthy male volunteers participated in both the Trier Social Stress Test (TSST) and a respective control procedure and then their brain activity was measured with functional MRI (fMRI) while they performed an emotional‐face‐recognition task. Sixteen participants were carriers of the short allele (ss/sl carriers) and 11 were homozygous for the long allele (ll carriers). Genotype groups were compared with respect to stress‐related physiological changes, memory performance, and brain activity. No significant genotype‐dependent effects on memory performance or cortisol levels were found. The ss/sl carriers showed significantly higher systolic and diastolic blood pressure than the ll carriers, independent of stress. The ss/sl carriers reported stronger stress‐induced nervous mood than the ll carriers. Our fMRI data revealed that the ss/sl carriers showed significantly weaker left hippocampus activation and stronger dorsomedial prefrontal cortex (dmPFC) deactivation when retrieving memories under stress as compared with the ll carriers. Subsequent analyses revealed that the distinct hippocampal activation pattern in both genotypes was associated with stress‐induced cortisol elevation, while the distinct dmPFC activation pattern in both genotypes was associated with stress‐induced changes in reaction times. Our results thus add new evidence that serotonin signaling modulates neural activity in the hippocampus and dmPFC during memory retrieval under acute psychosocial stress.