Accumulation of cadmium, zinc, and copper in maternal blood and developmental placental tissue:: Differences between Finland, Estonia, and St. Petersburg
Accumulation of cadmium, zinc, and copper in maternal blood and developmental placental tissue:: Differences between Finland, Estonia, and St. Petersburg
复制标题
DOI：
10.1006/enrs.1999.4043
复制
发表时间：
2000-05-01
影响因子：
8.3
通讯作者：
Vartiainen, T
中科院分区：
文献类型：
--
作者：
Kantola, M;Purkunen, R;Vartiainen, T
分析妊娠早期(n=)和足月(n=152)胎盘组织和血液中镉、锌、铜的含量，并测定新生儿福利和胎盘7-乙氧基香豆素O-脱乙基酶(ECOD)的体外活性。研究材料来自芬兰、爱沙尼亚和俄罗斯。结果表明，Cd在妊娠早期就开始在胎盘中积累，而锌和铜的含量在妊娠早期显著高于足月。在非吸烟者中，胎盘铜含量与新生儿出生体重呈负相关。在吸烟者中，胎盘锌含量与出生体重和ECOD活性呈正相关。出生体重与母亲吸烟的时间长短呈负相关。从圣彼得堡采集的样品中检测到的Cd浓度最高。这些数据表明，在整个怀孕期间，胎盘和母亲血液样本中的锌和镉呈反向积累。锌可能是人类胎盘生命功能的积极标志物，甚至是一种酶促作用。吸烟、胎次、年龄，尤其是居住地，会影响胎盘和母亲血液中Cd、Zn、Cu的含量和比率。(C)2000年学术出版社。
Cadmium, zinc, and copper from placental tissue and blood samples at the first trimester (n = 64) and at term (n = 152) were analyzed; the welfare of newborns and placental 7-eothoxycoumarin O-deethylase (ECOD) activities in vitro were determined. The study material was collected from Finland, Estonia, and Russia. The results demonstrate that Cd starts to accumulate in the placenta during the first trimester and that Zn and Cu contents were significantly higher at the first trimester than at term. Among nonsmokers a negative correlation was found between placental Cu content and birth weight of neonates. Among smokers a positive correlation between placental Zn content and birth weight and ECOD activity was found. The birth weights correlated inversely with the length of time the mothers smoked. The highest Cd concentrations were detected in the samples collected from St. Petersburg. The data demonstrate an inverse accumulation of Zn and Cd throughout the pregnancy in the placenta and maternal blood samples. Zn may act as a positive marker or even an enzymatic enhancement for the human placental vital functions. Smoking, parity, age, and especially the place of residence affect the Cd, Zn, and Cu contents and ratios in placenta and mother's blood. (C) 2000 Academic Press.