Intima media thickness in childhood obesity - Relations to inflammatory marker, glucose metabolism, and blood pressure
Intima media thickness in childhood obesity - Relations to inflammatory marker, glucose metabolism, and blood pressure
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DOI：
10.1016/j.metabol.2005.07.016
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发表时间：
2006-01-01
影响因子：
9.8
通讯作者：
Wunsch, R
中科院分区：
文献类型：
--
作者：
Reinehr, T;Kiess, W;Wunsch, R
儿童肥胖被认为与高血压、血脂异常、糖代谢受损和慢性炎症有关。在肥胖儿童中，尚未研究这些心血管危险因素中哪些与动脉内膜中层厚度(IMT)有关，IMT是早期动脉粥样硬化改变的非侵入性标志物。我们收集了96名肥胖儿童(中位年龄11岁)的临床资料(年龄、性别、青春期、体脂百分比、体重指数SD评分[SDS-BMI])，并测量了收缩压(SBP)、舒张压(DBP)、甘油三酯(TGS)、高密度脂蛋白胆固醇(高密度脂蛋白胆固醇)、低密度脂蛋白胆固醇(TG)、血糖、胰岛素、超敏C反应蛋白(HsCRP)。对照组由25名年龄、性别和青春期相同的非肥胖儿童组成。所有患者均采用14 MHz线性探头B超测定颈动脉内膜中层厚度。肥胖儿童显著高于正常儿童(P<0.05)。
Obesity in childhood is discussed to be associated with hypertension, dyslipidemia, impaired glucose metabolism, and chronic inflammation. It has not yet been studied in obese children which of these cardiovascular risk factors are related to intima media thickness (IMT), a noninvasive marker for early atherosclerotic changes. We collected the clinical data (age, sex, pubertal stage, percentage of body fat, SD score of body mass index [SDS-BMI]) and measured systolic blood pressure [SBP] and diastolic blood pressure [DBP], triglycerides [TGs], high- and low-density lipoprotein cholesterol, glucose, insulin, and high-sensitivity C-reactive protein [hsCRP]) in 96 obese children (median age, 11 years). The control group was composed of 25 nonobese children of the same age, sex, and pubertal stage. We determined the carotid IMT of all the patients by B-mode ultrasound with a 14-MHz linear transducer. Obese children demonstrated a significantly (P