Amyloid and tau PET demonstrate region-specific associations in normal older people.
Amyloid and tau PET demonstrate region-specific associations in normal older people.
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DOI：
10.1016/j.neuroimage.2017.02.051
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发表时间：
2017-04-15
期刊：
影响因子：
5.7
通讯作者：
Jagust WJ
中科院分区：
文献类型：
--
作者：
Lockhart SN;Schöll M;Baker SL;Ayakta N;Swinnerton KN;Bell RK;Mellinger TJ;Shah VD;O'Neil JP;Janabi M;Jagust WJ
β-淀粉样变性(A-β)和tau病理随着年龄的增长而变得越来越普遍，然而，这两种病理之间的空间关系仍不清楚。我们使用[18F]AV-1451(针对tau)和[11C]PiB(针对Aβ)正电子发射断层扫描和1.5T磁共振成像图像，在46名正常老年人中检测了这两种聚集蛋白之间的局部(相同区域)和非局部(不同区域)关联。虽然局部体素分析显示PIB和AV-1451示踪剂之间的关联主要在颞叶，但k-Means聚类显示，其中一些关联是由示踪剂保留率较低的区域驱动的。随后，我们进行了全脑区域(局部和非局部)的部分相关分析。我们计算了每个参与者在87个感兴趣区域(ROI)内的平均AV-1451和PIB摄取值。两两ROI分析显示许多与PIB-AV-1451呈正相关。重要的是，在联合皮质的多个区域的PIB和颞叶皮质ROI中的AV-1451之间发现了强烈的正部分相关性(控制了年龄、性别和全局灰质分数，p<；0.01)。此外，区域PIB与额顶叶AV-1451摄取之间的正相关也较少且较弱。特别是在颞叶ROI中，多个ROI位置的PIB可以很好地预测AV-1451摄取。这些数据表明，在认知正常的老年人中，Aβ和tau病理表现出显著的局部和非局部区域关联，整个皮质的PIB摄取增加与颞叶AV-1451摄取的增加相关。Aβ和tau积累之间的空间关系似乎不是Aβ所特有的，这表明无论Aβ在哪里积累，颞脑区域对tau积累的区域性易感性。
β-amyloid (Aβ) and tau pathology become increasingly prevalent with age, however, the spatial relationship between the two pathologies remains unknown. We examined local (same region) and non-local (different region) associations between these 2 aggregated proteins in 46 normal older adults using [18F]AV-1451 (for tau) and [11C]PiB (for Aβ) positron emission tomography (PET) and 1.5T magnetic resonance imaging (MRI) images. While local voxelwise analyses showed associations between PiB and AV-1451 tracer largely in the temporal lobes, k-means clustering revealed that some of these associations were driven by regions with low tracer retention. We followed this up with a whole-brain region-by-region (local and non-local) partial correlational analysis. We calculated each participant’s mean AV-1451 and PiB uptake values within 87 regions of interest (ROI). Pairwise ROI analysis demonstrated many positive PiB—AV-1451 associations. Importantly, strong positive partial correlations (controlling for age, sex, and global gray matter fraction, p < .01) were identified between PiB in multiple regions of association cortex and AV-1451 in temporal cortical ROIs. There were also less frequent and weaker positive associations of regional PiB with frontoparietal AV-1451 uptake. Particularly in temporal lobe ROIs, AV-1451 uptake was strongly predicted by PiB across multiple ROI locations. These data indicate that Aβ and tau pathology show significant local and non-local regional associations among cognitively normal elderly, with increased PiB uptake throughout the cortex correlating with increased temporal lobe AV-1451 uptake. The spatial relationship between Aβ and tau accumulation does not appear to be specific to Aβ location, suggesting a regional vulnerability of temporal brain regions to tau accumulation regardless of where Aβ accumulates.