Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure
Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure
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DOI：
10.1016/j.autneu.2006.10.008
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发表时间：
2007-03-30
影响因子：
2.7
通讯作者：
Lin, Tzu-Yu
中科院分区：
文献类型：
--
作者：
Chiu, Kuan-Ming;Chan, Hsiao-Lung;Lin, Tzu-Yu
导语：人的心脏跳动极不均匀，极不平稳。最近的研究表明，它属于一类被称为多重分形的信号。在充血性心力衰竭患者中也发现了多重分形性的丢失。我们研究了卡维地洛是否能恢复一组晚期充血性心力衰竭患者的多重分形特性。方法与结果：对10例晚期充血性心力衰竭患者在卡维地洛治疗前、治疗1个月及治疗3个月后进行Holler心电图检查。比较卡维地洛治疗前后的多重分形谱、去趋势波动分析(DFA)以及传统的心率变异性(HRV)参数，并与年龄、性别匹配的正常对照组进行比较。结果表明，在卡维地洛治疗期间，N-N间期时间序列的多重分形谱tau(Q)vs.Q恢复到正常。卡维地洛治疗3个月后，所有传统HRV参数和短期DFA均有明显改善。结论：卡维地洛可逆转晚期充血性心力衰竭患者多重分形性的恶化。(C)2006年，爱思唯尔出版。
Introduction: Human heart beats in an extremely inhomogeneous and non-stationary manner. Recent study has demonstrated that it belongs to a class of signals called multifractal. Loss of multifractality was also uncovered in patients with congestive heart failure. We investigated whether carvedilol could restore the multifractal properties in a group of patients with advanced congestive heart failure. Methods and results: A Holler ECG recording was obtained before and I and 3 months after titrated addition of carvedilol therapy in 10 patients with advanced congestive heart failure. Multifractal spectrum, detrended fluctuation analysis (DFA) as well as the traditional time- and frequency-domain heart rate variability (HRV) parameters were compared before and after carvedilol therapy together with those in age and sex-matched normal control. The results showed that the multifractal spectrum tau(q) vs. q of N-N interval time series returned toward normal during carvedilol treatment. All the tranditional HRV parameters and the short-term DFA improved significantly after 3 months of carvedilol therapy. Conclusion: We concluded that the deteriorated multifractal properties could be reversed by carvedilol treatment in patients with advanced congestive heart failure. (c) 2006 Published by Elsevier B.V.