Childhood height and birth weight in relation to future prostate cancer risk: a cohort study based on the copenhagen school health records register.
Childhood height and birth weight in relation to future prostate cancer risk: a cohort study based on the copenhagen school health records register.
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DOI：
10.1158/1055-9965.epi-13-0712
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Baker JL
中科院分区：
文献类型：
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作者：
Cook MB;Gamborg M;Aarestrup J;Sørensen TI;Baker JL
成人身高与前列腺癌风险呈正相关。然而，重要的暴露窗口目前尚不清楚，对早期生长期身高的评估也很少。此外，出生体重与前列腺癌之间的关系仍未确定。我们评估了哥本哈根学校健康记录注册（CSHRR）的队列中的这些关系。该中心有372 636名在校儿童。对于出生于20世纪30年代和1969年之间的男孩，出生体重和每年的儿童身高（在7岁到13岁之间测量）与前列腺癌风险的关系进行了分析。使用考克斯比例风险回归模型估计风险比（HR）和95%置信区间（95%CI）。共有125，211名男性进行分析，其中2，987人随后在257万人年的随访期间被诊断患有前列腺癌。在所有年龄段，身高z评分与前列腺癌风险显著相关（HR~1.13）。当比较相互校正模型的估计值时，13岁时的身高比身高变化（p=0.024）和7岁时的身高（p=0.024）更重要。调整出生体重并没有改变确定的估计数。出生体重与前列腺癌风险无关。儿童身高与前列腺癌风险之间的关联是由13岁时的身高驱动的。我们的研究结果表明，儿童晚期、青春期和成年期的生长期包含了关注的暴露窗口，这是身高和前列腺癌之间联系的基础。考虑到人类生长和致癌的复杂性，因果因素可能不是单一的。
Adult height has been positively associated with prostate cancer risk. However, the exposure window of importance is currently unknown and assessments of height during earlier growth periods are scarce. In addition, the association between birth weight and prostate cancer remains undetermined. We assessed these relationships a cohort of the Copenhagen School Health Records Register (CSHRR). The CSHRR comprises 372,636 school children. For boys born between the 1930’s and 1969, birth weight and annual childhood heights—measured between ages 7 and 13 years—were analyzed in relation to prostate cancer risk. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95 percent confidence intervals (95%CI). There were 125,211 males for analysis, 2,987 of who were subsequently diagnosed with prostate cancer during 2.57 million person-years of follow-up. Height z-score was significantly associated with prostate cancer risk at all ages (HR~1.13). Height at age 13 years was more important than height change (p=0.024) and height at age 7 years (p=0.024), when estimates from mutually adjusted models were compared. Adjustment of birth weight did not alter estimates ascertained. Birth weight was not associated with prostate cancer risk. The association between childhood height and prostate cancer risk was driven by height at age 13 years. Our findings implicate late childhood, adolescence and adulthood growth periods as containing the exposure window(s) of interest that underlies the association between height and prostate cancer. The causal factor may not be singular given the complexity of both human growth and carcinogenesis.