Damage-Fitness Model: Evaluation and synthesis
Damage-Fitness Model: Evaluation and synthesis
复制标题
损伤适应度模型：评估与综合
DOI：
10.1093/icb/icz060
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发表时间：
2019
影响因子：
2.6
通讯作者：
Heidinger, Britt
中科院分区：
文献类型：
--
作者：
Wada, Haruka;Heidinger, Britt
几十年来对压力反应的研究强调了个体、种群和物种之间的巨大差异，这种差异的来源一直是跨学科研究的中心。脊椎动物应激反应的最常见的措施是糖皮质激素。然而，糖皮质激素对健康的预测能力却出奇的低。这部分是因为激素水平响应于应激源暴露而迅速变化，并且在一个时间点升高的水平可以表明糖皮质激素正在帮助生物体科普应激源，或者激素释放的失调正在伤害生物体。这意味着，压力源的适应性后果取决于压力反应在消除压力源对细胞和组织的有害影响方面的效率。为了涵盖压力反应的效率的想法，并整合细胞和有机体的压力反应，一个新的理论模型称为损伤健身模型的开发。该模型侧重于应激反应的下游效应，并预测细胞和组织中损伤的累积（例如，对蛋白质、脂质和DNA的持续损伤）负面地影响健身成分。在这篇简短的评论中，我们研究了支持损害适应度模型的证据，并探索了新的发展方向。
Decades of research into stress responses have highlighted large variation among individuals, populations, and species, and the sources of this variation have been a center of research across disciplines. The most common measure of the vertebrate stress response is glucocorticoids. However, the predictive power of glucocorticoid responses to fitness is surprisingly low. This is partly because the hormone levels rapidly change in response to stressor exposure and elevated levels at one time point can indicate either that glucocorticoids are helping the organism cope with the stressor or that dysregulation of hormone release is harming the organism. Meaning, the fitness consequences of the stressor depends on how efficient the stress responses are at negating the harmful impacts of stressors to cells and tissues. To encompass the idea of the efficiency of stress responses and to integrate cellular and organismal stress responses, a new theoretical model called the Damage-Fitness Model was developed. The model focuses on the downstream effects of stress responses and predicts that the accumulation of damage in cells and tissues (e.g., persistent damage to proteins, lipids, and DNA) negatively impacts fitness components. In this mini-review, we examine evidence supporting the Damage-Fitness Model and explore new directions forward.