Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: A systematic review
Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: A systematic review
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DOI：
10.1213/01.ane.0000103187.70627.57
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发表时间：
2004-03-01
影响因子：
5.7
通讯作者：
Fleisher, LA
中科院分区：
文献类型：
--
作者：
Gupta, A;Stierer, T;Fleisher, LA
在这篇系统综述中，我们着重于四种不同麻醉技术的术后恢复和并发症。通过PubMed检索MEDLINE数据库（1966年至2002年6月），检索词为“麻醉”，门诊外科手术仅限于成人（bb0 - 19岁）、英语和人类的随机对照试验。第二种搜索策略结合了“异丙酚”、“异氟烷”、“七氟烷”或“地氟烷”这两个词。筛选和数据提取产生了58篇文章，这些文章被纳入最终的meta分析。异丙酚和异氟醚在早期恢复中没有差异。然而，地氟醚比异丙酚和异氟醚的早期恢复更快，七氟醚比异氟醚的早期恢复更快。七氟醚和异氟醚在麻醉就绪时间上有微小差异（5分钟），但在其他麻醉剂中没有差异。与异氟醚相比，异丙酚组恶心、呕吐、头痛和出院后恶心呕吐发生率均高于异氟醚组（P < 0.05）。吸入麻醉组患者数量较多，需要止吐剂组较异丙酚组为多。我们得出结论，不同麻醉药在早期恢复时间的差异很小，并有利于吸入麻醉药。异丙酚的副作用发生率，特别是术后恶心和呕吐发生率较低。
In this systematic review we focused on postoperative recovery and complications using four different anesthetic techniques. The database MEDLINE was searched via PubMed (1966 to June 2002) using the search words "anesthesia" and with ambulatory surgical procedures limited to randomized controlled trials in adults (>19 yr), in the English language, and in humans. A second search strategy was used combining two of the words "propofol," "isoflurane," "sevoflurane," or "desflurane ". Screening and data extraction produced 58 articles that were included in the final meta-analysis. No differences were found between propofol and isoflurane in early recovery. However, early recovery was faster with desflurane compared with propofol and isoflurane and with sevoflurane compared with isoflurane. A minor difference was found in home readiness between sevoflurane and isoflurane (5 min) but not among the other anesthetics. Nausea, vomiting, headache, and postdischarge nausea and vomiting incidence were in favor of propofol compared with isoflurane (P < 0.05). A larger number of patients in the inhaled anesthesia, groups required antiemetics compared with the propofol group. We conclude that the differences in early recovery times among the different anesthetics were small and in favor of the inhaled anesthetics. The incidence of side effects, specifically postoperative nausea and vomiting, was less frequent with propofol.