A LOW THRESHOLD CALCIUM SPIKE MEDIATES FIRING PATTERN ALTERATIONS IN PONTINE RETICULAR NEURONS
A LOW THRESHOLD CALCIUM SPIKE MEDIATES FIRING PATTERN ALTERATIONS IN PONTINE RETICULAR NEURONS
复制标题
DOI：
10.1126/science.3775364
复制
发表时间：
1986-11-07
期刊：
影响因子：
56.9
通讯作者：
MCCARLEY, RW
中科院分区：
文献类型：
--
作者：
GREENE, RW;HAAS, HL;MCCARLEY, RW
细胞内电记录在体外切片制备的脑干内侧脑桥网状结构，一个地区被认为是重要的调解despersonized睡眠现象，证明了一个人口的神经元，具有钙依赖性，低阈值尖峰。这种低阈值尖峰是灭活的数据相对去极化膜电位水平，当这种尖峰去灭活时，它诱导了动作电位的爆发。棘波的膜电位依赖性可能是与行为状态变化相关的动作电位不同模式变化的基础，因为内侧脑桥网状群神经元的基线膜电位在从清醒和慢波睡眠到去极化睡眠的过程中去极化，其特征在于没有爆发性放电。
Intracellular electrical recordings in an in vitro slice preparation of the brain stem medial pontine reticular formation, a region thought to be important in mediation of desynchronized sleep phenomena, demonstrate a population of neurons that have a calcium-dependent, low threshold spike. This low threshold spike was inactivated data relatively depolarized membrane potential levels and, when this spike was deinactivated, it induced a burst of action potentials. The membrane potential dependence of the spike may underlie changes in action potential differing patterns associated with behavioral state change because the baseline membrane potential in neurons of the medial pontine reticular population depolarizes during passage from waking and slow wave sleep to desynchronized sleep, which is characterized by the absence of burst firing.