Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross.
Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross.
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AKR/J x SWR/J 杂交 F2 小鼠体内脂肪的遗传性非常染色体效应。
DOI：
10.1007/s003359900554
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
West,DB
中科院分区：
文献类型：
--
作者：
York,B;Lei,K;West,DB
本研究描述了母系和父系效应对来自SWR/J × AKR/J杂交的F2雄性小鼠的肥胖、体重和单个脂肪垫重量的贡献。AKR/J小鼠在高脂肪饮食12周后变得肥胖，而SWR/J小鼠保持相对较瘦。在这里，我们报告说，与AKR母亲和AKR父亲的祖母的小鼠有显着更大的子宫和腹膜后脂肪垫比那些与SWR母亲和父亲的祖母。然而，祖父母品系对总体肥胖度（AI）或腹股沟、皮下或肠系膜脂肪垫的重量没有影响。爷爷奶奶的应变对体重有很小但很显著的影响。这些影响可归因于子宫内效应、印记效应、控制体脂的因子的细胞质和/或Y染色体传递。我们还描述了在X染色体上存在一个数量性状位点（QTL），接近DXMit 174，它与肥胖、体重和个体脂肪库的重量有关。然而，该QTL不负责上述祖父母品系效应。
In this study we describe the contribution of matrilineal and patrilineal effects on the adiposity, body weight, and on the weights of individual fat pads in F2male mice derived from an SWR/J × AKR/J cross. AKR/J mice become obese after 12 weeks on a high-fat diet, whereas SWR/J mice remain relatively lean. Here we report that mice with AKR maternal and AKR paternal grandmothers have significantly larger epidydimal and retroperitoneal fat pads than those with SWR maternal and paternal grandmothers. However, grandparental strain had no effect on the overall adiposity (AI) or the weights of the inguinal, subcutaneous or mesenteric fat pads. The strain of the paternal grandparents had a small but significant effect on body weight. These effects can be attributed to in utero effects, imprinting effects, cytoplasmic and/or Y chromosome transmission of factors controlling body fat. We also describe the presence of a quantitative trait locus (QTL) on Chromosome X, close toDXMit174,which is linked to adiposity, body weight, and to the weights of the individual fat depots. However, this QTL is not responsible for the grandparental strain effects described above.