Measuring eye states in functional MRI.
Measuring eye states in functional MRI.
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DOI：
10.1186/s12868-016-0282-7
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发表时间：
2016-07-13
期刊：
影响因子：
2.4
通讯作者：
Klingner CM
中科院分区：
文献类型：
--
作者：
Brodoehl S;Witte OW;Klingner CM
在许多功能性磁共振成像（fMRI）研究中，实验设计通常取决于眼睛状态（即，参与者的眼睛是睁着还是闭着）。在功能性磁共振成像过程中，闭上眼睛是一般的惯例，特别是当患者处于休息状态时，但眼睛的状态很难验证。虽然眼睛状态对大脑活动的影响的知识正在稳步增长，但只有少数研究小组实施了标准化程序来监测眼睛运动和眼睛状态。这些程序涉及昂贵的先进方法（例如，fMRI兼容相机）并且通常耗时（例如，EEG/EOG）。我们提出了一个简单的方法，区分开闭的眼睛，利用功能磁共振图像单独。14名健康受试者的fMRI数据证实了该方法的实用性，这些受试者必须根据预定的协议（3.0 T MRI扫描仪，EPI序列，3 × 3 × 3 mm体素，TR 2.52 s）睁眼和闭眼。本文提出的方法能够提取眼睛的运动方向。所有描述的方法都适用于前和后归一化的MR图像，并通过MATLAB工具箱免费提供。
In many functional magnetic resonance imaging (fMRI) studies, experimental design often depends on the eye state (i.e., whether the participants had their eyes open or closed). Closed eyes during an fMRI is the general convention, particularly when patients are in a resting-state, but the eye state is difficult to verify. Although knowledge of the impact of the eye state on brain activity is steadily growing, only a few research groups have implemented standardized procedures to monitor eye movements and eye state. These procedures involve advanced methods that are costly (e.g., fMRI-compatible cameras) and often time-consuming (e.g., EEG/EOG). We present a simple method that distinguishes open from closed eyes utilizing functional MR images alone. The utility of this method was demonstrated on fMRI data from 14 healthy subjects who had to open and close their eyes according to a predetermined protocol (3.0 T MRI scanner, EPI sequence with 3 × 3 × 3 mm voxels, TR 2.52 s). The method presented herein is capable of extracting the movement direction of the eyes. All described methods are applicable for pre- and post-normalized MR images and are freely available through a MATLAB toolbox.