Preparation of Magnetite-Containing Glass-Ceramics in Controlled Atmosphere for Hyperthermia of Cancer
Preparation of Magnetite-Containing Glass-Ceramics in Controlled Atmosphere for Hyperthermia of Cancer
复制标题
可控气氛下制备含磁铁矿微晶玻璃用于癌症热疗
DOI：
10.2109/jcersj.109.39
复制
发表时间：
2001
影响因子：
1.1
通讯作者：
T. Shinjo
中科院分区：
文献类型：
--
作者：
M. Kawashita;H. Takaoka;T. Kokubo;T. Yao;S. Hamada;T. Shinjo
亚铁磁性玻璃-陶瓷可用作癌症热疗的热籽晶，特别是那些位于身体深部的癌症，因为癌症通过磁铁矿的磁滞损耗而局部加热。当在癌症周围植入后，它们被放置在交变磁场下。在90 CO2 + 10 H2气氛中，以5°C/min的速率对组成为40 Fe 2 O3，29 CaO，31 SiO2，3 P2 O 5（重量比）的玻璃进行热处理。磁铁矿在650°C开始析出，随着热处理温度的升高，其晶粒尺寸和体积分数增加，在1150°C时分别达到150 nm和36 mass%。热处理样品的饱和磁化强度随热处理温度的升高而增加，在1150°C热处理后达到32.4emu/g。热处理后样品的矫顽力随热处理温度的升高而增加，在950°C时达到430 Oe，然后下降，在1150°C时达到150 Oe。在300 Oe和100 kHz下，在1150°C下热处理的试样显示出最大的发热量，为7.5 W/g。
Ferrimagnetic glass-ceramics are useful as thermoseeds for hyperthermia of cancers, especially those located at deep parts of the body, since cancers are locally heated by hysteresis loss of the magnetite. When, after implantation at around the cancer, they are placed under an alternating magnetic field. In the present study, a glass of composition 40Fe 2 O 3 , 29CaO, 31SiO 2 , 3P 2 O 5 (weight ratio) was heat-treated at a rate of 5°C/min in 90CO 2 +10H 2 atmosphere. Magnetite started to precipitate at 650°C, increased its crystallite size and volume fraction with increasing heat treatment temperature to reach 150 nm and 36 mass%, respectively at 1150°C. The saturation magnetization of heat-treated specimens increased with increasing heat treatment temperature to reach 32.4 emu/g after treatment at 1150°C. The coercive force of the heat-treated specimen increased with increasing heat treatment temperature to reach 430 Oe at 950°C, and then decreased to reach 150 Oe at 1150°C. The specimen heat-treated at 1150°C showed the maximum heat generation, 7.5 W/g, under 300 Oe and 100 kHz.