Getting to the root of miRNA-Mediated gene silencing
Getting to the root of miRNA-Mediated gene silencing
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DOI：
10.1016/j.cell.2007.12.024
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发表时间：
2008-01-11
期刊：
影响因子：
64.5
通讯作者：
Izaurralde, Elisa
中科院分区：
文献类型：
--
作者：
Eulalio, Ana;Huntzinger, Eric;Izaurralde, Elisa
MicroRNA类似于22个核苷酸长的RNA，其通过结合靶mRNA的3'非翻译区而在转录后沉默基因表达。尽管对它们的生物起源和生物学功能已经有了很多了解，但允许miRNAs沉默动物细胞中基因表达的机制仍然存在争议。在这里，我们讨论了目前的miRNA介导的基因沉默模型，并制定了一个假设，以调和差异。
MicroRNAs are similar to 22 nucleotide-long RNAs that silence gene expression posttranscriptionally by binding to the 3' untranslated regions of target mRNAs. Although much is known about their biogenesis and biological functions, the mechanisms allowing miRNAs to silence gene expression in animal cells are still under debate. Here, we discuss current models for miRNA-mediated gene silencing and formulate a hypothesis to reconcile differences.