Cancers related to lifestyle and environmental factors in France in 2015
Cancers related to lifestyle and environmental factors in France in 2015
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DOI：
10.1016/j.ejca.2018.09.009
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发表时间：
2018-12-01
影响因子：
8.4
通讯作者：
Bray, Freddie
中科院分区：
文献类型：
--
作者：
Soerjomataram, Isabelle;Shield, Kevin;Bray, Freddie
背景：癌症是法国过早患病和死亡的主要原因。为了量化癌症预防如何减轻负担，我们估计了2015年法国生活方式和环境风险因素对癌症发病率的贡献，并与其他高收入国家进行了比较。方法：吸烟、饮酒、饮食不足、超重和肥胖、缺乏身体活动、外源性激素、母乳喂养不佳、传染源、获得电离辐射、空气污染、紫外线暴露、职业暴露、饮用水砷和室内苯，以估计人群归因分数（PAF）和按癌症部位和性别的归因癌症数量。2015年，法国诊断出的所有新癌症中有41%（或346，000人中的142，000人）可归因于上述风险因素。男性的数量和PAF略高于女性（分别为84，000例与58，000例，44%与37%）。吸烟（PAF：20%）、饮酒（PAF：8%）、饮食因素（PAF：5%）和超重（PAF：5%）是最重要的因素。2015年，感染和职业暴露各占癌症病例的4%。结论：今天，法国五分之二的癌症可归因于可预防的风险因素。在法国负责相对于其他经济相似的国家的关键易受影响的因素的变化突出了需要量身定制的方法来癌症教育和预防。减少吸烟和饮酒以及采用更健康的饮食和体重仍然是减少法国未来几十年新增癌症患者数量的重要目标。(C)2018由Elsevier Ltd.出版
Background: Cancer is a major cause of premature illness and death in France. To quantify how cancer prevention could reduce the burden, we present estimates of the contribution of lifestyle and environmental risk factors to cancer incidence in France in 2015, comparing these with other high-income countries.Method: Prevalences of, and relative risks for tobacco smoking, alcohol consumption, inadequate diet, overweight and obesity, physical inactivity, exogenous hormones, suboptimal breastfeeding, infectious agents, ionising radiation, air pollution, ultraviolet exposure, occupational exposures, arsenic in drinking water and indoor benzene were obtained to estimate the population attributable fraction (PAF) and the number of attributable cancers by the cancer site and sex.Results: In 2015, 41% (or 142,000 of 346,000) of all new cancers diagnosed in France could be attributed to the aforementioned risk factors. The numbers and PAF were slightly higher in men than in women (84,000 versus 58,000 cases and 44% versus 37%, respectively). Smoking (PAF: 20%), alcohol consumption (PAF: 8%), dietary factors (PAF: 5%) and excess weight (PAF: 5%) were the most important factors. Infections and occupational exposures each contributed to an additional 4% of the cancer cases in 2015.Conclusion: Today, two-fifths of cancers in France are attributable to preventable risk factors. The variations in the key amenable factors responsible in France relative to other economically similar countries highlight the need for tailored approaches to cancer education and prevention. Reducing smoking and alcohol consumption and the adoption of healthier diet and body weight remain important targets to reduce the increasing number of new cancer patients in France in the decades to follow. (C) 2018 Published by Elsevier Ltd.