DEVELOPMENT OF INTESTINAL FLORA OF HUMAN-FLORA-ASSOCIATED (HFA) MICE IN THE INTESTINE OF THEIR OFFSPRING
DEVELOPMENT OF INTESTINAL FLORA OF HUMAN-FLORA-ASSOCIATED (HFA) MICE IN THE INTESTINE OF THEIR OFFSPRING
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DOI：
10.1538/expanim.44.219
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发表时间：
1995-07-01
影响因子：
2.4
通讯作者：
MITSUOKA, T
中科院分区：
文献类型：
--
作者：
HIRAYAMA, K;MIYAJI, K;MITSUOKA, T
比较了新生人类菌群相关（HFA）小鼠与新生常规（CV）小鼠肠道菌群的发育情况。CV和HFA小鼠从出生第一天起均检测到兼性厌氧菌，但第一周未检测到厌氧菌。厌氧菌从出生后第2周开始迅速增加，并在新生儿肠道中占主导地位。成年CV和HFA小鼠的肠道细菌大部分在出生后3周内分别定植在CV和HFA小鼠的肠道中。在HFA小鼠肠道中建立的人类肠道菌群最终在新生HFA小鼠肠道中繁殖，其组成没有明显变化。HFA小鼠肠道菌群的发育与CV小鼠相似，但与人类婴儿不同。这些结果表明，虽然HFA小鼠不能模拟人类婴儿肠道菌群的发育，但与HFA小鼠相关的人类菌群可以从母亲转移到后代。
Development of intestinal flora in newborn human-flora-associated (HFA) mice was compared with that in newborn conventional (CV) mice. Facultative anaerobes were detected from the first day after birth in both CV and HFA mice but anaerobes were not detected in the first week. Anaerobes rapidly increased from the 2nd week after birth and became predominant in newborn intestine. Most of the intestinal bacteria in adult CV and HFA mice were colonized in the intestine of CV and HFA mice, respectively, within 3 weeks after birth. The human intestinal flora established in the intestine of HFA mice finally reproduced without any remarkable change in composition in the intestine of newborn HFA mice. The development of intestinal flora in HFA mice was similar to that in CV mice but not that in human infants. These results indicated that human flora associated in HFA mice could be transferred from mothers to their offspring although HFA mice could not simulate the development of intestinal flora of the human infant.