Influence of slice thickness and reconstruction kernel on the computed tomographic attenuation of coronary atherosclerotic plaque
Influence of slice thickness and reconstruction kernel on the computed tomographic attenuation of coronary atherosclerotic plaque
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DOI：
10.1016/j.jcct.2010.01.013
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发表时间：
2010-03-01
影响因子：
5.4
通讯作者：
Marwan, Mohamed
中科院分区：
文献类型：
--
作者：
Achenbach, Stephan;Boehmer, Kerstin;Marwan, Mohamed
背景技术背景：冠状动脉粥样硬化斑块的计算机断层扫描（CT）衰减已被提出作为组织定征的标志，因此可能有助于斑块不稳定性的评估。目的：我们分析了重建参数对非钙化冠状动脉粥样硬化病变内测量的CT衰减的影响。对72例患者进行了对比增强双源CT冠状动脉成像研究（330毫秒旋转时间，2 × 64 × 0.6 mm准直，120 kV，400 mAs，80 mL造影剂，以6 mL/s静脉注射），共识别出100个不同的非钙化冠状动脉粥样硬化斑块。使用软（B20 f）、中等软（B26 f）和锐化（B46 f）重建内核重建图像数据集。使用中等软内核，以0.6/0.3 mm、0.75/0.4 mm和1.0/0.5 mm的层厚/增量重建图像数据集。结果：使用中等软核的平均CT衰减为109 +/- 58 HU（范围，-16至168 HU）。使用软核，平均密度为113 +/- 57 HU（范围：-13至169 HU），使用尖核，平均密度为97 +/- 49 HU（范围：-23至131 KU）。同样，重建层厚对测量的CT衰减有显著影响（中等软核的平均值：0.6mm、0.75 mm和1.0 mm层厚分别为102 +/- 52 HU、109 +/- 58 HU和113 +/- 57 HU）。0.75-mm和0.6-mm层厚之间的差异（P = 0.05）和中等尖锐和尖锐内核之间的差异（P = 0.02）有统计学意义。结论：图像重建显着影响非钙化冠状动脉粥样硬化斑块的CT衰减。随着空间分辨率的降低（更软的内核或更厚的切片），CT衰减显著增加。因此，使用绝对CT衰减值进行斑块表征可能是有问题的。(C)2010年心血管计算机断层扫描学会。All rights reserved.
BACKGROUND: The computed tomographic (CT) attenuation of coronary atherosclerotic plaque has been proposed as a marker for tissue characterization and may thus potentially contribute to the assessment of plaque instability.OBJECTIVE: We analyzed the influence of reconstruction parameters on CT attenuation measured within noncalcified coronary atherosclerotic lesions.METHODS: Seventy-two patients were studied by contrast-enhanced dual-source CT coronary angiography (330 millisecond rotation time, 2 X 64 X 0.6 mm collimation, 120 kV, 400 mAs, 80 mL contrast agent intravenously at 6 mL/s), and a total of 100 distinct noncalcified coronary atherosclerotic plaques were identified. Image data sets were reconstructed with a soft (B20f), medium soft (B26f), and sharp (B46f) reconstruction kernel. With the medium soft kernel, image data sets were reconstructed with a slice thickness/increment of 0.6/0.3 mm, 0.75/0.4 mm, and 1.0/0.5mm. Within each plaque, CT attenuation was measured.RESULTS: Mean CT attenuation using the medium soft kernel was 109 +/- 58 HU (range, -16 to 168 HU). Using the soft kernel, mean density was 113 +/- 57 HU (range, -13 to 169 HU), and using a sharp kernel, mean density was 97 +/- 49 HU (range, -23 to 131 KU). Similarly, reconstructed slice thickness had a significant influence on the measured CT attenuation (mean values for medium soft kernel: 102 +/- 52 HU versus 109 +/- 58 HU versus 113 +/- 57 HU for 0.6mm, 0.75-mm, and 1.0-mm slice thickness). The differences between 0.75-mm and 0.6-mm slice thickness (P = 0.05) and between medium sharp and sharp kernels (P = 0.02) were statistically significant.CONCLUSIONS: Image reconstruction significantly influences CT attenuation of noncalcified coronary atherosclerotic plaque. With decreasing spatial resolution (softer kernel or thicker slices), CT attenuation increases significantly. Using absolute CT attenuation values for plaque characterization may therefore be problematic. (C) 2010 Society of Cardiovascular Computed Tomography. All rights reserved.