Chance and necessity in chromosomal gene distributions
Chance and necessity in chromosomal gene distributions
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DOI：
10.1016/j.tig.2008.02.004
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发表时间：
2008-05-01
影响因子：
11.4
通讯作者：
Teichmann, Sarah
中科院分区：
文献类型：
--
作者：
Hermsen, Rutger;ten Wolde, Pieter Rein;Teichmann, Sarah
通过分析染色体上基因的间距，我们发现编码区外的转录和RNA加工调控序列在基因间距离的分布上留下了足迹。利用染色体上的基因和一维气体之间的类比，我们构建了一个统计零模型。我们用它来估计不同物种中典型的上游和下游调控序列大小。与该模型的偏差揭示了酿酒酵母中的双向转录调控区和大肠杆菌中的双向终止子。
By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.