Functional Micropeptides Encoded by Long Non-Coding RNAs: A Comprehensive Review.
Functional Micropeptides Encoded by Long Non-Coding RNAs: A Comprehensive Review.
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长非编码 RNA 编码的功能性微肽：综合综述
DOI：
10.3389/fmolb.2022.817517
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
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作者：
Long non-coding RNAs (lncRNAs) were originally defined as non-coding RNAs (ncRNAs) which lack protein-coding ability. However, with the emergence of technologies such as ribosome profiling sequencing and ribosome-nascent chain complex sequencing, it has been demonstrated that most lncRNAs have short open reading frames hence the potential to encode functional micropeptides. Such micropeptides have been described to be widely involved in life-sustaining activities in several organisms, such as homeostasis regulation, disease, and tumor occurrence, and development, and morphological development of animals, and plants. In this review, we focus on the latest developments in the field of lncRNA-encoded micropeptides, and describe the relevant computational tools and techniques for micropeptide prediction and identification. This review aims to serve as a reference for future research studies on lncRNA-encoded micropeptides.
