A new method for drug application to the inner ear
A new method for drug application to the inner ear
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DOI：
10.1159/000089407
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Iguchi, F
中科院分区：
文献类型：
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作者：
Ito, J;Endo, T;Iguchi, F
内耳感觉细胞非常容易受到损伤，并且损伤后恢复非常困难。最近有报道称，包括神经营养因子在内的几种药物可以预防内耳损伤。这项实验研究的目的是寻找将药物应用于内耳的新方法，以有效防止内耳损伤。以可生物降解的水凝胶为载体，通过圆窗膜将脑源性神经营养因子（BDNF）注入豚鼠内耳。应用 BDNF 后，由于耳毒性治疗损伤内耳毛细胞和螺旋神经节神经元，存活的螺旋神经节神经元数量增加。这一结果表明 BDNF 可以有效保护内耳免受损伤，并且可生物降解的水凝胶可用于将药物应用于内耳。版权所有 (C) 2005 S. Karger AG，巴塞尔。
Inner ear sensory cells are very susceptible to injuries and recovery after damage is very difficult. Recently several drugs including neurotrophic factors have been reported to protect against inner ear injury. The purpose of this experimental study is to find new methods for applying drugs to the inner ear that effectively protect against inner ear damage. Biodegradable hydrogel was used as a carrier for application of brain-derived neurotrophic factor ( BDNF) into the inner ear of guinea pigs through the round window membrane. After application of BDNF the number of surviving spiral ganglion neurons increased following injury of inner ear hair cells and spiral ganglion neurons by ototoxic treatment. This result indicates that BDNF provides effective protection against inner ear damage and that biodegradable hydrogel is useful for application of drugs to the inner ear. Copyright (C) 2005 S. Karger AG, Basel.