Prospective study of dietary patterns and persistent cough with phlegm among Chinese Singaporeans
Prospective study of dietary patterns and persistent cough with phlegm among Chinese Singaporeans
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DOI：
10.1164/rccm.200506-901oc
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发表时间：
2006-02-01
影响因子：
24.7
通讯作者：
London, SJ
中科院分区：
文献类型：
--
作者：
Butler, LM;Koh, WP;London, SJ
理论基础：使用主成分分析来检验饮食模式是对个体食物和营养摄入量与健康结果的评估的补充，但尚未被应用于非恶性呼吸系统疾病或症状。目的：在新加坡华人队列中检验基线饮食摄取模式与新发的持续性咳嗽和痰的关系。方法：在1993年基线时，当面进行了165个条目的食物频率调查。我们通过电话访问从1999年到2004年在52,325名受试者中确认了623例偶发咳嗽伴痰。我们确定了两种不同的食物模式：以猪肉和鸡肉点心食物和面食为特征的“肉-点心”模式和以蔬菜、水果和豆类食物为特征的“蔬菜-水果-酱油”模式。主要结果：肉-点心模式与新发的咳嗽伴痰成正相关(优势比，1.43；95%可信区间，1.08，1.89；在调整了年龄、性别、总能量摄入量、吸烟、教育程度和非淀粉多糖类摄入量后，在这个队列中，咳嗽伴痰的保护性因素出现了。较弱的相关性与更多的慢性症状和偶发哮喘有关。在调整非淀粉多糖摄入量后，蔬菜-水果-大豆模式的微弱负相关性消失。结论：富含肉类、钠和精制碳水化合物的饮食可能增加患咳嗽伴痰的风险，而与新加坡华人队列中高纤维饮食的明显益处无关。
Rationale: Using principal components analysis to examine dietary patterns complements the evaluation of individual food and nutrient intake in relation to health outcomes, but has not yet been applied to nonmalignant respiratory disease or symptoms.Objective: To examine the relation between patterns of dietary intake at baseline and new onset of persistent cough with phlegm in a population-based cohort of Singapore Chinese.Methods: A 165-item validated food frequency questionnaire was administered in-person at baseline in 1993. We identified 623 cases of incident cough with phlegm among 52,325 subjects by telephone interview from 1999 through 2004. We identified two distinct food patterns: a "meat-dim sum" pattern characterized by pork and chicken dim sum foods and noodle dishes, and a "vegetable-fruit-soy" pattern characterized by vegetables, fruit, and soyfood items.Main Results: The meat-dim sum pattern was positively associated with new-onset cough with phlegm (odds ratio, 1.43; 95% confidence interval, 1.08, 1.89; comparing fourth to first quartile, p for trend = 0.02), after adjustment for age, sex, total energy intake, smoking, education, and nonstarch polysaccharide intake, a protective factor for cough with phlegm in this cohort. Weaker associations were seen for more chronic symptoms and for incident asthma. A weak inverse association for the vegetable-fruit-soy pattern disappeared after adjustment for nonstarch polysaccharide intake.Conclusion: A diet rich in meats, sodium, and refined carbohydrates may increase risk of developing cough with phlegm, independently of the apparent beneficial effects of a diet high in fiber in this Singapore Chinese cohort.