Inflammation-coagulation network: are serine protease receptors the knot?
Inflammation-coagulation network: are serine protease receptors the knot?
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DOI：
10.1016/s0165-6147(00)01469-3
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发表时间：
2000-05-01
影响因子：
13.8
通讯作者：
Cicala, C
中科院分区：
文献类型：
--
作者：
Cirino, G;Napoli, C;Cicala, C
受伤后，身体会产生一种机制来划定和修复组织损伤；这种现象被称为炎症。在这个过程中被激活的几种不同的途径中，这是生存所必需的，凝血途径的激活是一个关键特征。事实上，血液流动性的临床变化与持续的炎症密切相关。最近的证据表明，丝氨酸蛋白酶受体可能在凝血和炎症之间的宿主防御机制中发挥重要作用。
Following an injury, the body recruits a mechanism to delimit and repair tissue damage; this phenomenon is known as inflammation. Among the several different pathways that are activated during this process, which is necessary for survival, activation of the coagulation pathway is a key feature. In fact, clinical changes in blood fluidity have been closely related to ongoing inflammation. Recent evidence suggests that serine protease receptors might play a major role in the host defence mechanism at the interface between coagulation and inflammation.