Regulation of WASP/WAVE proteins: making a long story short.
Regulation of WASP/WAVE proteins: making a long story short.
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DOI：
10.1083/jcb.200403127
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发表时间：
2004-09-27
影响因子：
7.8
通讯作者：
Caron, Emmanuelle
中科院分区：
文献类型：
--
作者：
Bompard, Guillaume;Caron, Emmanuelle
尽管它们的同源性，WASP和WAVE的调节，Arp 2/3依赖性肌动蛋白聚合的激活剂，一直被认为是不同的。最近的几项研究揭示了其调控的新方面，突出了其复杂性和翻译后修饰的关键作用。新的数据还表明了WASP家族蛋白的其他功能，促使我们重新考虑现有的模型。
Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.