LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.
LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.
复制标题
LARP1转录后调节MTOR并有助于癌症的进展。
作者：
RNA结合蛋白（RBP）结合并转录后调节mRNA的稳定性。La相关蛋白1（LARP 1）是一种与多聚腺苷酸结合蛋白相互作用的保守的RBP，参与调节寡聚嘧啶序列（TOP）mRNA的翻译。在这里，我们发现LARP 1与3000种富含癌症途径的mRNA复合。LARP 1相互作用组的一个重要成员是mTOR，其mRNA转录物由LARP 1稳定。在功能水平上，我们发现LARP 1促进细胞迁移，侵袭，锚定非依赖性生长和体内肿瘤发生。此外，我们发现LARP 1表达在上皮癌如宫颈癌和非小细胞肺癌中升高，其表达分别与疾病进展和不良预后相关。因此，我们得出结论，通过转录后调节基因，如癌症通路中的mTOR，LARP 1有助于癌症的进展。
RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression.
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影响因子：
16
作者：
Mukherjee N;Corcoran DL;Nusbaum JD;Reid DW;Georgiev S;Hafner M;Ascano M Jr;Tuschl T;Ohler U;Keene JD
通讯作者：
Keene JD
影响因子：
6.2
作者：
Liu, Dan;Huang, Yi;Li, Weimin
通讯作者：
Li, Weimin
影响因子：
--
作者：
Nagaraja, Ankur K.;Creighton, Chad J.;Matzuk, Martin M.
通讯作者：
Matzuk, Martin M.
影响因子：
20.4
作者：
Dhillon, Tony;Mauri, Francesco A.;Seckl, Michael J.
通讯作者：
Seckl, Michael J.
DOI：
10.1126/science.1199498
发表时间：
2011-06-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hsu PP;Kang SA;Rameseder J;Zhang Y;Ottina KA;Lim D;Peterson TR;Choi Y;Gray NS;Yaffe MB;Marto JA;Sabatini DM
通讯作者：
Sabatini DM