Contribution of the renin-angiotensin system and of the sympathetic nervous system to blood pressure homeostasis during chronic restriction of sodium intake.
Contribution of the renin-angiotensin system and of the sympathetic nervous system to blood pressure homeostasis during chronic restriction of sodium intake.
复制标题
长期限制钠摄入期间肾素-血管紧张素系统和交感神经系统对血压稳态的贡献。
DOI：
10.1093/ajh/1.4.353
复制
发表时间：
1988
影响因子：
3.2
通讯作者：
B. Trimarco
中科院分区：
文献类型：
--
作者：
M. Volpe;G. Lembo;A. Morganti;M. Condorelli;B. Trimarco
在之前的一篇论文中，我们表明，在长期、适度限制钠摄入量期间，交感神经系统活动仅受到短暂刺激，而血浆肾素活性则持续升高。然而，低盐饮食期间刺激肾素-血管紧张素系统对维持血压稳态的贡献仍不清楚。为了研究这个问题，在正常钠摄入量（150 mEq/d）期间、转换酶抑制后（依那普利 20 mg/d po）以及与转换酶（CEI）慢性抑制相关的一个月钠摄入限制（50 mEq/d）期间，测量了 8 名正常受试者的血压、心率、血浆儿茶酚胺、肾素活性和醛固酮。在低盐饮食和 CEI 期间，血浆肾素活性因 CEI 显着升高。此外，即使血浆去甲肾上腺素和直立心率显着且持续增加，与对照值相比，在研究过程中进行的所有测量中仍观察到血压下降。我们的研究结果支持这样的假设：肾素-血管紧张素系统激活在低盐饮食期间维持血压稳态中发挥重要作用。事实上，在有效阻断血管紧张素 II 形成的情况下，尽管交感神经系统同时受到持续刺激，但血压仍会降低。
In a previous paper, we showed that during a long-term, moderate restriction in sodium intake, sympathetic nervous system activity was only transiently stimulated, whereas a sustained rise of plasma renin activity occurred. However, the contribution from stimulation of the renin-angiotensin system in the maintenance of blood pressure homeostasis during a low-salt diet is still unclear. To investigate this issue, in eight normal subjects blood pressure, heart rate, plasma catecholamines, renin activity, and aldosterone were measured during normal sodium intake (150 mEq/d), after converting-enzyme inhibition (enalapril 20 mg/d po), and during one month of sodium intake restriction (50 mEq/d) associated with chronic inhibition of converting-enzyme (CEI). During a low-salt diet with CEI, plasma renin activity rose significantly as a result of CEI. In addition, even in the presence of a marked and sustained increase in plasma norepinephrine and in upright heart rate, a decrease in blood pressure was observed in all the measurements performed during the course of the study as compared to the control values. Our findings support the hypothesis that renin-angiotensin system activation plays an important role in the maintenance of blood pressure homeostasis during a low-salt diet. In fact, in the presence of an effective blockade of angiotensin II formation, blood pressure is decreased, despite the concurrent, sustained stimulation of the sympathetic nervous system.