Contributions of serotonin in addiction vulnerability.
Contributions of serotonin in addiction vulnerability.
复制标题
DOI：
10.1016/j.neuropharm.2011.03.022
复制
发表时间：
2011-09
影响因子：
4.7
通讯作者：
Winstanley CA
中科院分区：
文献类型：
--
作者：
Kirby LG;Zeeb FD;Winstanley CA
血清素（5-羟色胺；5-HT）系统长期以来一直与情绪相关，其失调与情绪和焦虑症的病理生理学有关。虽然滥用药物对 5-HT 神经传递的调节也已得到认可，但其在药物成瘾和药物复发易感性中的作用是最近的研究焦点。首先，我们回顾了支持血清素中缝核及其前脑预测作为药物滥用目标的临床前数据，重点是精神兴奋剂、阿片类药物和乙醇的影响。接下来，我们研究 5-HT 受体在冲动中的作用，冲动是导致成瘾和复发的脆弱性的核心行为。最后，我们讨论了共病情绪和成瘾性疾病中血清素能失调的证据，并提出了治疗成瘾和预防药物复发的新血清素能靶点。
The serotonin (5-hydroxytryptamine; 5-HT) system has long been associated with mood and its dysregulation implicated in the pathophysiology of mood and anxiety disorders. While modulation of 5-HT neurotransmission by drugs of abuse is also recognized, its role in drug addiction and vulnerability to drug relapse is a more recent focus of investigation. First, we review preclinical data supporting the serotonergic raphe nuclei and their forebrain projections as targets of drugs of abuse, with emphasis on the effects of psychostimulants, opioids and ethanol. Next, we examine the role of 5-HT receptors in impulsivity, a core behavior that contributes to the vulnerability to addiction and relapse. Finally, we discuss evidence for serotonergic dysregulation in comorbid mood and addictive disorders and suggest novel serotonergic targets for the treatment of addiction and the prevention of drug relapse.