Recombination and nondisjunction in humans and flies
Recombination and nondisjunction in humans and flies
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DOI：
10.1093/hmg/5.supplement_1.1495
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发表时间：
1996-01-01
影响因子：
3.5
通讯作者：
Hassold, T
中科院分区：
文献类型：
--
作者：
Koehler, KE;Hawley, RS;Hassold, T
最近对果蝇和人类的研究表明，异常的遗传重组是这两个物种不分离的重要组成部分。在这两种情况下，不分离的比例与配对和/或重组失败有关，并且在这两种情况下，太远或太近的交换增加了不分离的可能性。在这篇综述中，我们提供了两个角度对这些意见：第一，审查交换和模式生物的染色体分离，重点是果蝇，其次概述了人类的不分离。这种形式使我们能够描述从模式生物的研究中发展出来的范式，并询问这些范式是否适用于人类的情况。
Recent studies of Drosophila and humans indicate that aberrant genetic recombination is an important component of nondisjunction in both species. In both, a proportion of nondisjunction is associated with failure to pair and/or recombine and in both, exchanges which are either too distal or too proximal increase the likelihood of malsegregation. In this review we provide two perspectives on these observations: first, a review of exchange and chromosome segregation in model organisms, focusing on Drosophila, and secondly an overview of nondisjunction in humans. This format allows us to describe the paradigms developed from studies of model organisms and to ask whether these paradigms apply to the human situation.