People who binge drink show neuroendocrine tolerance to alcohol cues that is associated with immediate and future drinking- results from a randomized clinical experiment.
People who binge drink show neuroendocrine tolerance to alcohol cues that is associated with immediate and future drinking- results from a randomized clinical experiment.
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一项随机临床实验的结果表明，酗酒的人对酒精信号表现出神经内分泌耐受性，这与当前和未来的饮酒有关。
DOI：
10.1038/s41386-023-01735-9
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Claus,EricD
中科院分区：
文献类型：
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作者：
Blaine,SaraK;Ridner,Clayton;Campbell,Benjamin;Crone,Lily;Macatee,Richard;Ansell,EmilyB;Robinson,JenniferL;Claus,EricD
对酒精的神经内分泌耐受性，即，对酒精的皮质醇反应减弱，与严重酒精使用障碍（AUD）的腹内侧前额叶皮质（VmPFC）酒精线索反应性和复发风险有关，但其在AUD发展中的作用尚不清楚。最近的研究表明，在酗酒（BD）的人对酒精线索的迟钝皮质醇反应可能在消费大量酒精的动机中发挥作用，但这种失调的内分泌反应和BD对酒精线索的神经反应之间的联系尚不清楚。为了验证这一点，根据他们最近的饮酒史招募了两组参与者。在两个独立的7 T功能磁共振成像（fMRI）扫描中，33名BD和31名非暴饮暴食的社交饮酒者（SD）暴露于酒精线索和水线索。每次扫描之后，都进行了酒精味觉测试（ATT），测试酒精的内隐动机，并在实验后对他们的“真实的世界”饮酒行为进行了为期一个月的前瞻性测量。在每次扫描过程中，重复收集血浆，以检查酒精线索和酒精消耗对皮质醇水平的单独影响。相对于水的线索和SD，BD表现出迟钝的皮质醇线索的反应性，与VmPFC线索的反应性呈负相关。在BD中，钝化的皮质醇和更大的VmPFC线索反应与扫描后一个月内立即和未来的饮酒量有关。因此，BD的神经内分泌耐受性可能与线索的激励显著性增加有关，并在机制上有助于增加AUDs发展中的酒精消费。
Neuroendocrine tolerance to alcohol, i.e., a blunted cortisol response to alcohol, has been linked to Ventromedial Prefrontal Cortex (VmPFC) alcohol cue reactivity and relapse risk in severe Alcohol Use Disorders (AUDs), but its role in the development of AUDs is not clear. Recent work suggests that blunted cortisol responses to alcohol cues in individuals who engage in binge drinking (BD) may play a role in motivation to consume larger amounts of alcohol, but the link between this dysregulated endocrine response and BD’s neural responses to alcohol cues remains unclear. To examine this, two groups of participants were recruited based on their recent drinking history. Thirty-three BD and 31 non-binging, social drinkers (SD) were exposed to alcohol cues and water cues in two separate 7 T functional magnetic resonance imaging (fMRI) scans. Each scan was followed by the Alcohol Taste Test (ATT) of implicit motivation for alcohol and a post-experiment, one-month prospective measurement of their “real world” drinking behavior. During each scan session, blood plasma was collected repeatedly to examine the separate effects of alcohol cues and alcohol consumption on cortisol levels. Relative to water cues and SD, BD demonstrated blunted cortisol cue reactivity that was negatively associated with VmPFC cue reactivity. In BD, both blunted cortisol and greater VmPFC cue reactivity were related to immediate and future alcohol consumption in the month following the scans. Thus, neuroendocrine tolerance in BD may be associated with increased incentive salience of cues and contribute mechanistically to increased alcohol consumption seen in the development of AUDs.