LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.
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DOI：
10.1016/j.bbcan.2015.07.001
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Mandal SS
中科院分区：
文献类型：
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作者：
Bhan A;Mandal SS
非编码RNA（Non-coding RNA，ncRNA）是一类新兴的调控RNA，在基因调控、染色质动力学、细胞分化、发育等多种细胞和生理过程中发挥重要作用。ncRNA调节各种生物过程和人类疾病的机制仍然是难以捉摸的。HOX反义基因间RNA（HOTAIR）是近年来发现的一种在基因调控和染色质动力学中起重要作用的长链非编码RNA（lncRNA），在多种肿瘤中表现为表达失调。HOTAIR与关键的表观遗传调节因子如组蛋白甲基转移酶PRC 2和组蛋白脱甲基酶LSD 1相互作用，并调节基因沉默。在这里，我们回顾了最近的进展，了解HOTAIR的功能和调节及其与癌症和其他疾病的关系。
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in various cellular and physiological processes such as in gene regulation, chromatin dynamics, cell differentiation, development etc. NcRNAs are dysregulated in a variety of human disorders including cancers, neurological disorders, and immunological disorders. The mechanisms through which ncRNAs regulate various biological processes and human diseases still remain elusive. HOX antisense intergenic RNA (HOTAIR) is a recently discovered long non-coding RNA (lncRNA) that plays critical role in gene regulation and chromatin dynamics, appears to be misregulated in a variety of cancers. HOTAIR interacts with key epigenetic regulators such as histone methyltransferase PRC2 and histone demethylase LSD1 and regulates gene silencing. Here, we have reviewed recent advancements in understanding the functions and regulation of HOTAIR and its association with cancer and other diseases.