Transneuronal effects triggered by saphenous nerve injury on one side of a rat are restricted to neurones of the contralateral, homologous nerve
Transneuronal effects triggered by saphenous nerve injury on one side of a rat are restricted to neurones of the contralateral, homologous nerve
复制标题
大鼠一侧隐神经损伤引发的跨神经元效应仅限于对侧同源神经的神经元
DOI：
10.1016/0304-3940(91)90393-8
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
C. Passant
中科院分区：
文献类型：
--
作者：
J. Kolston;S. Lisney;M.N.C. Mulholland;C. Passant
大鼠一侧隐神经的横断和再生降低了对侧隐神经在逆行神经刺激后引起血浆外渗的能力。有人提出，一种跨神经元信号--即从身体一侧的受损神经元通过脊髓传递到另一侧的完好神经元的信号--参与触发这种反应。目前的实验表明，这种跨神经元信号的影响仅限于动物两侧同源神经的神经元，即它从一侧的隐神经神经元传递到另一侧的隐神经神经元;它的影响似乎没有延伸到其他神经中的神经元，例如同侧或对侧腓肠神经中的神经元。
Transection and regeneration of the saphenous nerve on one side of a rat reduces the ability of the contralateral saphenous nerve to evoke plasma extravasation following antidromic nerve stimulation. It is proposed that a transneuronal signal - that is a signal that passes from injured neurones on one side of the body to intact ones on the other via the spinal cord - is involved in triggering this response. The present experiments have shown that the influence of this transneuronal signal is restricted to neurones of homologous nerves on the two sides of an animal, i.e. it passes from saphenous nerve neurones on one side to saphenous nerve neurones on the other; its influence does not seem to extend to neurones in other nerves, for example ones in either the ipsi- or contralateral sural nerves.