Between-subject transfer of emotional information evokes specific pattern of amygdala activation
Between-subject transfer of emotional information evokes specific pattern of amygdala activation
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DOI：
10.1073/pnas.0511302103
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发表时间：
2006-03-07
影响因子：
11.1
通讯作者：
Werka, T
中科院分区：
文献类型：
--
作者：
Knapska, E;Nikolaev, E;Werka, T
动物或人类表现出的情绪状态会严重影响其同类的行为。杏仁核在情绪处理中起着至关重要的作用。在这项研究中，我们描述了一个实验大鼠模型的主题之间的情绪信息转移和它对杏仁核激活的影响。大鼠成对饲养，一只动物（指定为“示范者”）接受特定的行为训练，包括足部电击强化情境条件反射或仅暴露于新的情境。接下来，我们研究了演示者对其笼友（称为“观察者”）的探索行为和观察者的声学惊吓反应的表现的影响。我们报告说，我们可以区分两组观察员从控制动物（如所示的惊吓反应措施）和观察员之间的区别（通过索引的探索），关于他们是否与示威者处理不同的实验条件。此外，我们表明，观察员的杏仁核激活（如c-Fos映射所示）的示威者相同的水平，在中央杏仁核的情况下，甚至更高的水平。此外，观察者的c-Fos表达水平反映了与他们配对的示威者的特定行为治疗。因此，在这项研究中，我们已经表明，同居大鼠传递的未定义的情感信息可以被评估和测量，它会引起杏仁核非常强烈的信息特异性激活。
Emotional states displayed by an animal or a human can seriously affect behavior of their conspecifics. The amygdala plays a crucial role in the processing of emotions. in this study, we describe an experimental rat model of between-subject transfer of emotional information and its effects on activation of the amygdala. The rats were kept in pairs, and one animal (designated as "demonstrator") was treated to specific behavioral training of either foot-shock-reinforced context conditioning or just exposure to a novel context. We next examined the influence of the demonstrators on the exploratory behavior of their cagemates (called "observers") and the observers' performance of the acoustic startle response. We report that we can distinguish both groups of observers from the control animals (as shown by startle-response measure) and distinguish between observers (by means of indexing the exploration), with respect to whether they were paired with demonstrators treated to different experimental conditions. Furthermore, we show that the observers have most of their amygdala activated (as revealed by c-Fos mapping) to the same level as the demonstrators and, in the case of the central amygdala, to an even higher level. Moreover, the level of c-Fos expression in the observers reflected the specific behavioral treatment of the demonstrators with whom they were paired. Thus, in this study, we have shown that undefined emotional information transferred by a cohabitant rat can be evaluated and measured and that it evokes very strong and information-specific activation of the amygdala.