Engineering nanocellulose hydrogels for biomedical applications
Engineering nanocellulose hydrogels for biomedical applications
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DOI：
10.1016/j.cis.2019.03.002
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发表时间：
2019-05-01
影响因子：
15.6
通讯作者：
Garnier, Gil
中科院分区：
文献类型：
--
作者：
Curvello, Rodrigo;Raghuwanshi, Vikram Singh;Garnier, Gil
纳米纤维素水凝胶是具有良好机械性能的高度水合多孔纤维素软材料。这些基于纤维素的凝胶可以由细菌或植物纤维素纳米原纤维产生，其是亲水的、可再生的、可生物降解的和生物相容的。纳米纤维素，无论是原纤维（CNF）、晶体（CNC）还是细菌（BNC），都具有高纵横比和表面积，并且可以用官能团或通过接枝生物分子进行化学修饰。纤维素功能化提供了增强的物理和化学性质以及生物相互作用的控制，使其水凝胶适合于特定的应用。在这里，我们严格审查纳米纤维素水凝胶的生物医学应用。纳米纤维素水凝胶已被证明用于3D细胞培养，模拟细胞外基质（ECM）特性，具有低细胞毒性。对于伤口敷料和软骨修复，纳米纤维素凝胶促进细胞再生，同时为组织工程支架提供所需的机械性能。纳米纤维素内治疗剂的包封允许药物的靶向递送。目前，纤维素与肽和蛋白质的交联使得新一代低成本和可再生的智能材料能够用于诊断。最后，水凝胶中所含的纤维的有序网状结构推动了生物分子和细胞分离的应用。纳米纤维素水凝胶已成为多种生物医学应用的高度工程化平台，为生命科学提供可再生和高性能的解决方案。Crown版权所有（C）2019由Elsevier B.V.发布。保留所有权利。
Nanocellulose hydrogels are highly hydrated porous cellulosic soft materials with good mechanical properties. These cellulose-based gels can be produced from bacterial or plant cellulose nanofibrils, which are hydrophilic, renewable, biodegradable and biocompatible. Nanocellulose, whether fibrils (CNF), crystals (CNC) or bacterial (BNC), has a high aspect ratio and surface area, and can be chemically modified with functional groups or by grafting biomolecules. Cellulose functionalization provides enhanced physical and chemical properties and control of biological interactions, tailoring its hydrogels for specific applications. Here, we critically review nanocellulose hydrogels for biomedical applications. Nanocellulose hydrogels have been demonstrated for 3D cell culture, mimicking the extracellular matrix (ECM) properties with low cytotoxicity. For wound dressing and cartilage repair,, nanocellulose gels promote cell regeneration while providing the required mechanical properties for tissue engineering scaffolds. The encapsulation of therapeutics within nanocellulose allows the targeted delivery of drugs. Currently, cellulose crosslinking to peptides and proteins enables a new generation of low cost and renewable smart materials used in diagnostics. Last, the organized mesh of fibres contained in hydrogels drives applications in separation of biomolecules and cells. Nanocellulose hydrogels have emerged as a highly engineerable platforrh for multiple biomedical applications, providing renewable and performant solutions to life sciences. Crown Copyright (C) 2019 Published by Elsevier B.V. All rights reserved.