Frequency of Bone Marrow Lesions and Association with Pain Severity: Results from a Population-based Symptomatic Knee Cohort
Frequency of Bone Marrow Lesions and Association with Pain Severity: Results from a Population-based Symptomatic Knee Cohort
复制标题
骨髓病变的频率及其与疼痛严重程度的关联：基于人群的症状性膝关节队列的结果
DOI：
10.3899/jrheum.100587
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
J. Cibere
中科院分区：
文献类型：
--
作者：
Stephen Ip;E. C. Sayre;A. Guermazi;S. Nicolaou;H. Wong;Anona Thorne;J. Singer;J. Kopec;J. Esdaile;J. Cibere
Objective.在一个基于人群的症状性早期膝关节骨关节炎（OA）队列中，评价骨髓病变（BML）的患病率及其与疼痛严重程度的相关性。方法.膝关节疼痛受试者（n = 255），年龄40-79岁，通过X线片和磁共振成像（MRI）进行评价，并分为OA分期：无OA（NOA）、X线片前OA（PROA）和X线片OA（罗阿）。6个区域的BML分级为0-3级（无、轻度、中度、重度），定义为（1）BMLsum = 6个评分之和;（2）BMLmax =任何区域的最差评分。通过西安大略和麦克马斯特大学OA指数（WOMAC）评估疼痛。完成线性回归分析，以评估总WOMAC疼痛（主要结局）与BMLsum或BMLmax的相关性。次要结局为WOMAC行走疼痛和WOMAC爬楼梯疼痛。所有分析均校正了年龄、性别、体重指数、OA分期、关节积液和关节损伤。结果11%的NOA、38%的PROA和71%的罗阿受试者存在BML（p < 0.001）。未观察到BMLsum或BMLmax与总WOMAC疼痛或行走疼痛相关。然而，BMLsum与爬楼梯疼痛相关[回归系数（RC）= 0.09，95% CI 0.00-0.18]。BMLmax与爬楼梯疼痛相关，与重度BML的相关性最强（RC 0.60，95% CI 0.04-1.17）。结论在该症状性膝关节队列中，38%的PROA和71%的罗阿受试者存在BML。BML与爬楼梯疼痛显著相关，但与总WOMAC或行走疼痛无关。
Objective. To evaluate the prevalence of bone marrow lesions (BML) and their association with pain severity in a population-based cohort of symptomatic early knee osteoarthritis (OA). Methods. Subjects with knee pain (n = 255), age 40–79 years, were evaluated by radiograph and magnetic resonance imaging (MRI) and classified into OA stages: no OA (NOA), preradiographic OA (PROA), and radiographic OA (ROA). BML were graded 0–3 (none, mild, moderate, severe) in 6 regions and defined as (1) BMLsum = the sum of 6 scores; and (2) BMLmax = the worst score at any region. Pain was assessed by the Western Ontario and McMaster Universities OA Index (WOMAC). Linear regression analysis was completed to assess the association of Total WOMAC Pain (primary outcome) versus BMLsum or BMLmax. Secondary outcomes were WOMAC Pain on Walking and WOMAC Pain on Climbing Stairs. All analyses were adjusted for age, sex, body mass index, OA stage, joint effusion, and meniscal damage. Results. BML were present in 11% of NOA, 38% of PROA, and 71% of ROA subjects (p < 0.001). No association was seen for BMLsum or BMLmax versus Total WOMAC Pain or Pain on Walking. However, BMLsum was associated with Pain on Climbing Stairs [regression coefficients (RC) = 0.09, 95% CI 0.00–0.18]. BMLmax was associated with Pain on Climbing Stairs, with the strongest association for severe BML (RC 0.60, 95% CI 0.04–1.17). Conclusion. BML were present in 38% of PROA and 71% of ROA subjects in this symptomatic knee cohort. BML were significantly associated with Pain on Climbing Stairs but not Total WOMAC or Pain on Walking.
影响因子：
19.7
作者：
Crema, Michel D.;Roemer, Frank W.;Guermazi, Ali
通讯作者：
Guermazi, Ali
影响因子：
--
作者：
Felson, David T.;Niu, Jingbo;Aliabadi, Piran
通讯作者：
Aliabadi, Piran
影响因子：
7
作者：
Sowers, MF;Hayes, C;Welch, G
通讯作者：
Welch, G