Effects of a short-term suspension of hormone replacement therapy on mammographic density
Effects of a short-term suspension of hormone replacement therapy on mammographic density
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DOI：
10.1016/s0015-0282(01)01967-7
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发表时间：
2001-09-01
影响因子：
6.7
通讯作者：
del Vecchio, W
中科院分区：
文献类型：
--
作者：
Colacurci, N;Fornaro, F;del Vecchio, W
目的：评价激素替代疗法（HRT）和短期暂停HRT对乳腺摄影密度的影响。设计：前瞻性临床研究。设置：那不勒斯第二大学门诊绝经诊所。患者：97名健康绝经后妇女。干预措施：39例子宫完整的绝经期妇女（A组）连续透皮给予E-2加醋酸诺美孕酮治疗，手术绝经妇女37例（B组），连续给予E-2透皮给药，对照组21例（C组）。在入组时和12个月后，在不暂停HRT的情况下进行乳房X线摄影（A1组：19名女性; B1组：19名女性）或短期停药后（A2组：20名妇女; B2组：18名妇女）。主要结果测量：根据定量方法评估乳腺摄影密度。结果：在第二次乳房X线摄影时，A1组中的7名患者、B1组中的4名患者以及A2和B2组中的1名患者显示乳房X线摄影密度增加，而在C组患者中未观察到乳房X线摄影密度增加。A1组与A2组比较，差异有统计学意义（P < 0. 05），B1组与B2组比较，差异无统计学意义（P > 0. 05）。结论：暂停HRT 3周左右可逆转HRT引起的乳腺密度增高。（Fertil Steril（R）2001;76：451-5. (C)2001年由美国生殖医学学会出版。
Objective: To evaluate the effects of hormone replacement therapy (HRT) and of a short-term suspension of HRT on mammographic density.Design: Prospective clinical study.Setting: Outpatient menopausal clinic of the Second University of Naples.Patient(s): Ninety-seven healthy postmenopausal women.Intervention(s): Thirty-nine menopausal women with intact uterus (group A) were treated with continuous transdermal E-2 plus acetate nomegestrolo sequentially added, 37 women in surgical menopause (group B) were treated with transdermal E-2 continuously administered, and 21 menopausal women did not receive any medication (group C). At the entry and after 12 months, a mammography was performed without suspension of HRT (group A1: 19 women; group B1: 19 women) or after a short-term suspension (group A2: 20 women; group B2: 18 women).Main Outcome Measure(s): Mammographic density evaluated according to a quantitative method.Result(s): At the second mammography, seven patients in group A1, four patients in group B1, and one patient in both groups A2 and B2 showed an increase in mammographic density, whereas no mammographic density increase was observed in patients in group C. A statistically significant difference in the mammographic density increase was found between group A1 and group A2; no difference was found between group B1 and B2.Conclusion(s): Suspension of HRT for about 3 weeks may reverse mammographic density increase associated with its use. (Fertil Steril(R) 2001;76:451-5. (C) 2001 by American Society for Reproductive Medicine.).