The plasma jet kINPen - A powerful tool for wound healing
The plasma jet kINPen - A powerful tool for wound healing
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DOI：
10.1016/j.cpme.2016.01.001
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发表时间：
2016-07-01
影响因子：
--
通讯作者：
von Woedtke, Thomas
中科院分区：
文献类型：
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作者：
Bekeschus, Sander;Schmidt, Anke;von Woedtke, Thomas
冷大气压等离子体源的开发是多年前等离子体医学创新领域的起点。今天，大量的信息是关于等离子体的生物医学和临床应用。在后者中，伤口愈合是特别感兴趣的，因为已经有有前景的研究证明了等离子体在治疗慢性伤口中的益处。伤口愈合受到氧化还原机制的严格调节。这创造了一个令人兴奋的机会，因为我们和其他人已经确定活性氧和氮物质是介导冷等离子体生物效应的核心成分。因此，将等离子体产生的物质定向递送到细胞和组织可以开始新的治疗选择，不仅在病理性伤口的愈合中，而且还与其他基于氧化还原的疾病有关。文献涵盖了许多关于冷物理等离子体源的生物效应的发现。然而，等离子体源彼此差异很大，使得从物理和生物学的角度总结甚至比较来自不同类型源的结果具有挑战性。本综合综述的目的是提供一个独特的研究概要，评估与暴露于大气压氩等离子体射流kINPen相关的临床前和临床相关性以及潜在健康风险。这种经过充分研究和有前途的血浆来源证明了在不久的将来具有临床意义的强大潜力。此外，研究其生物学效应的研究集合可作为类似血浆来源和血浆医学领域应用的榜样。(C)2016年爱思唯尔有限公司。All rights reserved.
The development of cold atmospheric pressure plasma sources was the starting point for the innovative field of plasma medicine many years ago. Today, a large body of information is available on the biomedical and clinical applications of plasma. Among the latter, wound healing is of special interest as there have been promising studies demonstrating a benefit of plasma in the treatment of chronic wounds. Wound healing is tightly regulated by redox mechanisms. This creates an exciting opportunity as we and others have identified reactive oxygen and nitrogen species to be the central components mediating biological effects of cold plasma. A directed delivery of the plasma-generated species to cells and tissues may therefore commence new therapeutic options not only in the healing of pathological wounds but also related to other redox-based diseases. The literature covers numerous findings on the biological effects of cold physical plasma sources. However, plasma sources strongly differ from each other making it challenging to summarize or even compare results from different types of sources from a physical and biological point of view. The aim of this comprehensive review is to provide a unique compendium of studies assessing the pre-clinical and clinical relevance as well as potential health risks related to the exposure to the atmospheric pressure argon plasma jet kINPen. This well-investigated and promising plasma source demonstrates a strong potential to be of clinical significance in the near future. Also, the collection of studies investigating its biological effects may serve as a role model for similar plasma sources and applications in the field of plasma medicine. (C) 2016 Elsevier GmbH. All rights reserved.