Routine synthesis of L-[18F]6-fluorodopa with fluorine-18 acetyl hypofluorite.
Routine synthesis of L-[18F]6-fluorodopa with fluorine-18 acetyl hypofluorite.
复制标题
用氟-18乙酰次氟酸常规合成L-[18F]6-氟多巴。
作者：
M. Adam;T. Ruth;J. Grierson;B. Abeysekera;B. Pate
L-[18 F]6-氟多巴（2.4-10.6 mCi）的合成是通过在室温下使气态[18 F]乙酰基次氟酸通过L-甲基-N-乙酰基-[β-（3-甲氧基-4-乙酰氧基苯基）]丙氨酸酯在乙酸中的溶液，然后用浓异硫氰酸水解中间产物来进行的。通过高效液相色谱法在100分钟的总合成时间内以8%EOB放射化学产率分离所需的氟多巴异构体。
The synthesis of L-[18F]6-fluorodopa (2.4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N- acetyl-[beta-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydriodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.