Elongated membrane zones boost interactions of diffusing proteins.
Elongated membrane zones boost interactions of diffusing proteins.
复制标题
拉长的膜区域增强了扩散蛋白质的相互作用。
DOI：
10.1016/j.cell.2011.08.003
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发表时间：
2011
期刊：
影响因子：
64.5
通讯作者：
Hess,SamuelT
中科院分区：
文献类型：
--
作者：
Zimmerberg,Joshua;Hess,SamuelT
生物膜是二维的，这使得膜蛋白质的准一维扩散的发现令人困惑。Jaqaman等人（2011）现在显示肌动球蛋白和微管蛋白相互作用以建立长而薄的扩散走廊，从而增加选择的膜蛋白的有效浓度以促进它们的相互作用并调节信号传导。
Biological membranes are two dimensional, making the discovery of quasi-one-dimensional diffusion of membrane proteins puzzling. Jaqaman et al. (2011) now show that actomyosin and tubulin interact to establish long, thin diffusion corridors, thereby increasing the effective concentration of select membrane proteins to promote their interactions and modulate signaling.