In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance
In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance
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DOI：
10.2337/diabetes.51.10.3102
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发表时间：
2002-10-01
期刊：
影响因子：
7.7
通讯作者：
Graessler, J
中科院分区：
文献类型：
--
作者：
Kopprasch, S;Pietzsch, J;Graessler, J
氧化低密度脂蛋白（oxLDL）是动脉粥样硬化形成的关键介质和冠状动脉疾病（CAD）的标志物。2型糖尿病与过度的心血管发病率和死亡率相关。由于动脉粥样硬化发生在糖尿病诊断之前，我们研究了葡萄糖耐量受损（IGT）患者循环oxLDL水平是否升高。对376例糖耐量正常（NGT）、113例IGT和54例新诊断的2型糖尿病患者的OxLDL水平进行了检测。校正年龄和BMI后，IGT组血清oxLDL水平显著高于NGT组（P = 0.002）。OxLDL水平与血液中氧化/抗氧化平衡的以下参数无关：总抗氧化能力、尿酸-尿囊素比率和循环吞噬细胞氧合活性。在逐步多变量分析中，LDL胆固醇（P < 0.0005）和甘油三酯（P < 0.0005）是循环oxLDL水平的最强预测因子，其次是HDL胆固醇（P = 0.003）、攻毒后2小时C肽（P = 0.011）、空腹游离脂肪酸（P = 0.013）和血清对氧磷酶活性（P = 0.035）。oxLDL与LDL胆固醇和甘油三酯的强相关性表明IGT中的LDL氧化优先与血脂异常相关。氧化低密度脂蛋白的增加可以解释高致动脉粥样硬化的潜力血脂异常在糖尿病前期状态。
Oxidized LDL (oxLDL) is a key mediator in atherogenesis and a marker of coronary artery disease (CAD). Type 2 diabetes is associated with excessive cardiovascular morbidity and mortality. Because atherogenesis starts before diabetes is diagnosed, we investigated whether circulating oxLDL levels are increased in impaired glucose tolerance (IGT). OxLDL levels were measured in 376 subjects with normal glucose tolerance (NGT), 113 patients with IGT, and 54 patients with newly diagnosed type 2 diabetes. After correction for age and BMI, serum levels of oxLDL were significantly increased in IGT versus NGT subjects (P = 0.002). OxLDL levels were not associated with the following parameters of the oxidative/antioxidative balance in the blood: total antioxidant capacity, urate-to-allantoin ratio, and circulating phagocyte oxygenation activity. In stepwise multivariate analysis, LDL cholesterol (P < 0.0005) and triglycerides (P < 0.0005) were the strongest predictors of circulating oxLDL levels, followed by HDL cholesterol (P = 0.003), 2-h postchallenge C-peptide (P = 0.011), fasting free fatty acids (P = 0.013), and serum paraoxonase activity (P = 0.035). The strong correlation of oxLDL with LDL cholesterol and triglycerides indicates that LDL oxidation in IGT is preferentially associated with dyslipidemia. OxLDL increase may explain the high atherogenic potency of dyslipidemia in the prediabetic state.