Shaping fat distribution: New insights into the molecular determinants of depot- and sex-dependent adipose biology.
Shaping fat distribution: New insights into the molecular determinants of depot- and sex-dependent adipose biology.
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DOI：
10.1002/oby.21133
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Karastergiou K
中科院分区：
文献类型：
--
作者：
Fried SK;Lee MJ;Karastergiou K
回顾了解调节脂肪分布的细胞机制的最新进展。我们重点介绍了使用新方法（包括谱系追踪）的研究揭示的关于脂肪组织发育起源和生长的库差异和性别差异的新见解。正常生长过程中脂肪分布的变化以及对营养或激素状态变化的反应是由每个脂肪库中发现的细胞的内在差异驱动的。不同解剖脂肪组织中的脂肪祖细胞和前脂肪细胞源自决定其增殖和分化能力的细胞谱系。因此，生长和重塑过程中肥大和增生的速率因库而异。脂肪细胞的能力还取决于关键转录因子和非编码 RNA 表达的变化。这些发育事件受到性染色体、激素和营养信号的影响，这些信号决定了每个储存库的脂肪形成、代谢和功能特性。我们对脂肪分布理解的这些新进展为理解非肥胖和肥胖男性和女性的体型与健康之间的关系提供了坚实的基础。
To review recent advances in understanding the cellular mechanisms that regulate fat distribution. We highlight new insights into depot- and sex-differences in the developmental origins and growth of adipose tissues as revealed by studies that use new methods, including lineage tracing. Variations in fat distribution during normal growth and in response to alterations in nutritional or hormonal status are driven by intrinsic differences in cells found in each adipose depot. Adipose progenitor cells and preadipocytes in different anatomical adipose tissues derive from cell lineages that determine their capacity for proliferation and differentiation. As a result, rates of hypertrophy and hyperplasia during growth and remodeling vary among depots. The capacities of adipose cells are also determined by variations in the expression of key transcription factors and non-coding RNAs. These developmental events are influenced by sex chromosomes, hormonal and nutrient signals that determine the adipogenic, metabolic, and functional properties of each depot. These new developments in our understanding of fat distribution provide a sound basis for understanding the association of body shape and health in non-obese and obese men and women.