High-Mobility Group Box-1 and Liver Disease.
High-Mobility Group Box-1 and Liver Disease.
复制标题
高动力组框1和肝病。
DOI：
10.1002/hep4.1223
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发表时间：
2018-09
影响因子：
5.1
通讯作者：
Nieto N
中科院分区：
文献类型：
--
作者：
Gaskell H;Ge X;Nieto N
高迁移率族蛋白1（HMGB 1）是一种普遍存在的蛋白质。虽然最初认为HMGB 1由于其DNA结合能力而只是一种结构蛋白，但过去十年的证据表明，HMGB 1是参与急性肝损伤和慢性肝病发病机制的关键蛋白。当它在损伤后被动释放或主动分泌时，HMGB 1作为损伤相关的分子模式，通过晚期糖基化终产物受体或Toll样受体4等将损伤和炎症传递给邻近细胞。在急性肝损伤的情况下，HMGB 1参与缺血/再灌注、脓毒症和药物诱导的肝损伤。在慢性肝病的背景下，它与酒精性肝病、肝纤维化、非酒精性脂肪性肝炎和肝细胞癌有关。最近，已经确定了特定的翻译后修饰，可以调节蛋白质在肝脏中的作用。在这里，我们提供了一个详细的审查HMGB 1信号如何参与急性肝损伤和慢性肝病。
High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis of acute liver injury and chronic liver disease. When it is passively released or actively secreted after injury, HMGB1 acts as a damage‐associated molecular pattern that communicates injury and inflammation to neighboring cells by the receptor for advanced glycation end products or toll‐like receptor 4, among others. In the setting of acute liver injury, HMGB1 participates in ischemia/reperfusion, sepsis, and drug‐induced liver injury. In the context of chronic liver disease, it has been implicated in alcoholic liver disease, liver fibrosis, nonalcoholic steatohepatitis, and hepatocellular carcinoma. Recently, specific posttranslational modifications have been identified that could condition the effects of the protein in the liver. Here, we provide a detailed review of how HMGB1 signaling participates in acute liver injury and chronic liver disease.
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