Delivery of molecular and cellular medicine to solid tumors
Delivery of molecular and cellular medicine to solid tumors
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DOI：
10.1016/s0168-3659(97)00237-x
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发表时间：
1998-04-30
影响因子：
10.8
通讯作者：
Jain, RK
中科院分区：
文献类型：
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作者：
Jain, RK
为了到达肿瘤中的癌细胞，血液传播的治疗分子或细胞必须进入肿瘤的血管并穿过血管壁进入血管，最后通过血管壁迁移。不幸的是，肿瘤的发展往往会阻碍这些步骤中的每一个步骤。我们的研究目标是从实验和理论上分析这些步骤中的每一个，然后将所得信息整合到一个统一的理论框架中。这种分析和综合的范例使我们能够更好地了解实体瘤中的生理障碍，并开发新的策略来利用和/或克服这些障碍，以改善癌症的检测和治疗。(C)1998年Elsevier Science B.V.
To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment. (C) 1998 Elsevier Science B.V.