Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency
Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency
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DOI：
10.1007/s00774-015-0694-y
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发表时间：
2016-07-01
影响因子：
3.3
通讯作者：
Okano, Toshio
中科院分区：
文献类型：
--
作者：
Tsugawa, Naoko;Uenishi, Kazuhiro;Okano, Toshio
目前关于健康青少年血清25-羟基维生素D（25 OHD）和甲状旁腺激素（PTH）浓度以及骨矿物质状态的信息不足，无法设定参考值。本研究旨在提供日本青少年维生素D状况的可比数据，并评估维生素D不足易感性的性别差异。本文测定了1,380名12-18岁健康青少年血清25 OHD和PTH浓度。受试者完成了一份关于运动史、饮食和生活方式因素的问卷。通过定量超声评价跟骨硬度。男孩和女孩的血清25 OHD浓度分别为60.8 +/- 18.3和52.8 +/- 17.0 nmol/L。大约30%的男孩和47%的女孩的25 OHD浓度低于最佳水平（< 50 nmol/L）。男生血清PTH浓度与血清25 OHD浓度呈负相关，女生血清PTH浓度与钙摄入量呈负相关，而与血清25 OHD无相关性。与此相反，在跟骨硬度的增量作为血清25 OHD升高的结果是女孩高于男孩。由于维生素D缺乏症在日本青少年中很常见，据估计，男孩和女孩分别需要摄入千分之一日元12和千分之一日元14微克/天的维生素D才能达到50 nmol/L的25 OHD浓度。此外，本研究的结果表明，维生素D缺乏症与女孩的跟骨硬度比男孩有更大的关联。
There is currently insufficient information on serum 25-hydroxyvitamin D (25OHD) and parathyroid hormone (PTH) concentrations, and bone mineral status in healthy adolescents to allow reference values to be set. This study aimed to provide comparable data on vitamin D status in Japanese adolescents and to assess sex differences in susceptibility to vitamin D insufficiency. Serum 25OHD and PTH concentrations were measured in 1,380 healthy adolescents (aged 12-18 years). Subjects completed a questionnaire on exercise history, diet, and lifestyle factors. Calcaneal stiffness was evaluated by quantitative ultrasound. Serum 25OHD concentrations in boys and girls were 60.8 +/- 18.3 and 52.8 +/- 17.0 nmol/L, respectively. Approximately 30 % of boys and 47 % of girls had suboptimal 25OHD concentrations (< 50 nmol/L). Serum PTH concentration was negatively correlated with serum 25OHD concentration in boys, but negatively correlated with calcium intake rather than serum 25OHD in girls. In contrast, the increment in calcaneal stiffness as a result of elevation of serum 25OHD was higher in girls than in boys. As vitamin D deficiency is common in Japanese adolescents, it was estimated that intakes of a parts per thousand yen12 and a parts per thousand yen14 mu g/day vitamin D would be required to reach 25OHD concentrations of 50 nmol/L in boys and girls, respectively. Moreover, the results of the present study indicate that vitamin D deficiency has a greater association with calcaneal stiffness in girls than in boys.