Microvascular flow and tissue Po2 in skeletal muscle of chronic reduced renal mass hypertensive rats
Microvascular flow and tissue Po2 in skeletal muscle of chronic reduced renal mass hypertensive rats
复制标题
DOI：
10.1152/ajpheart.2000.279.5.h2295
复制
发表时间：
2000-11-01
影响因子：
4.8
通讯作者：
Tonellato, PJ
中科院分区：
文献类型：
--
作者：
Lombard, JH;Frisbee, JC;Tonellato, PJ
本研究确定是否小动脉血流量，毛细血管红细胞（RBC）速度，毛细血管红细胞压积（Hct（cap）），和组织Po-2的改变，在提睾肌的大鼠慢性肾性质量性高血压（RRM-HT）相对于正常血压大鼠高或低盐（NT-HS与NT-LS）饮食。无论是在静息状态还是在10（-4）M腺苷最大程度舒张血管期间，NT和HT大鼠的一级至三级小动脉中的血流量均无差异。静息时各组间毛细血管RBC流速相似，但在腺苷灌注期间RRM-HT和NT-HS大鼠中升高。与NT-LS相比，RRM-HT和NT-HS大鼠在静息时Hct（cap）降低，RRM-HT大鼠在腺苷诱导的扩张期间Hct（cap）降低。在对照条件下，RRM-HT和NT-HS大鼠的组织Po-2与NT-LS大鼠相比有所减少，并且在腺苷诱导的扩张过程中，RRM-HT大鼠的组织Po-2低于NT-LS大鼠。这些结果表明，RRM-HT和血压正常大鼠长期暴露于高盐饮食导致组织氧合减少，尽管维持正常的小动脉血流。
This study determined whether arteriolar blood flow, capillary red blood cell (RBC) velocity, capillary hematocrit (Hct(cap)), and tissue Po-2 are altered in cremaster muscles of rats with chronic reduced renal mass hypertension (RRM-HT) relative to normotensive rats on high- or low-salt (NT-HS vs. NT-LS) diet. The blood flow in first- through third-order arterioles was not different between NT and HT rats, either at rest or during maximal relaxation of the vessels with 10(-4) M adenosine. Capillary RBC velocity was similar between the groups at rest but was elevated in RRM-HT and NT-HS rats during adenosine superfusion. Hct(cap) was reduced at rest in RRM-HT and NT-HS rats compared with NT-LS and was reduced in RRM-HT rats during adenosine-induced dilation. Tissue Po-2 was reduced in RRM-HT and NT-HS rats compared with NT-LS rats during control conditions and was lower in RRM-HT than in NT-LS rats during adenosine-induced dilation. These results indicate that both RRM-HT and chronic exposure of normotensive rats to a high-salt diet lead to reduced tissue oxygenation, despite the maintenance of normal arteriolar blood flow.