Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile Parkinsonism:: First case report
Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile Parkinsonism:: First case report
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DOI：
10.1002/mds.20384
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发表时间：
2005-05-01
影响因子：
8.6
通讯作者：
Inoue, K
中科院分区：
文献类型：
--
作者：
Suzuki, M;Hattori, N;Inoue, K
用~（123）I-MIBG心肌放射性造影术观察原发性帕金森病（PD）患者心肌对~（123）I-MIBG的摄取减少。然而，常染色体隐性遗传的青少年帕金森综合征（AR-JP），由parkin基因引起的患者，在这里显示正常的I-123-MIBG心肌摄取，这表明AR-JP是一个不同的疾病实体PD。虽然AR-JP的临床特征有时与晚发性特发性PD非常相似，但I-123-MIBG心肌显像可能是区分PD与其他帕金森综合征（包括AR-JP）的有力工具。© 2005运动障碍协会。
A decrease in myocardial uptake of iodine- 123-labeled metaiodobenzylguanidine ((123) I-MIBG) has been reported in idiopathic Parkinson's disease (PD) using I-123-MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR-JP), caused by the parkin gene, presented here showed normal I-123-MIBG myocardial uptake, suggesting that AR-JP is a distinct disease entity from PD. Although the clinical features of AR-JP are sometimes quite similar to those of late-onset idiopathic PD, I-123-MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR-JP. © 2005 Movement Disorder Society.