FAILURE TO DISCRIMINATE CONSPECIFICS IN AMYGDALOID-LESIONED MICE
FAILURE TO DISCRIMINATE CONSPECIFICS IN AMYGDALOID-LESIONED MICE
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DOI：
10.1016/0091-3057(94)90331-x
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发表时间：
1994-07-01
影响因子：
3.6
通讯作者：
WATANABE, S
中科院分区：
文献类型：
--
作者：
BORLONGAN, CV;WATANABE, S
本实验采用条件性个体偏爱（CIP）方法，即一种改进的条件性位置偏爱（CPP）范式，研究了杏仁核在小鼠辨别行为中的作用。受试小鼠的CIP训练包括连续6天交替IP注射吗啡（3 mg/kg）或盐水，然后与偏好框的一个隔室中的刺激小鼠相关联。CIP训练后，受试小鼠在吗啡相关刺激小鼠和盐水相关刺激小鼠之间进行选择。正常和假手术小鼠表现出对吗啡相关刺激小鼠的偏好。另一方面，在CIP训练之前或之后接受双侧杏仁核损伤的小鼠对任一刺激小鼠都没有表现出任何偏好。这些结果支持了杏仁核可能通过其阿片受体与外周注射吗啡的中枢相互作用来影响小鼠条件性辨别行为的表达和获得的观点。
An experiment was conducted to investigate the role of the amygdala in the discriminative behavior of mice using the conditioned individual preference (CIP) method, a modified conditioned place preference (CPP) paradigm. CIP training of the subject mice involved 6 consecutive days of alternate IP injections of morphine (3 mg/kg) or saline followed by associations with a stimulus mouse in one compartment of the preference box. After the CIP training, the subject mice were given a choice between the morphine-associated and the saline-associated stimulus mice. Normal and sham-operated mice showed preference for the morphine-associated stimulus mouse. On the other hand, mice receiving bilateral amygdala lesions before or after CIP training did not show any preference for either stimulus mouse. These results support the view that the amygdala influences expression and acquisition of conditioned discriminant behaviors of mice by possibly interacting centrally, through its opiate receptors, with the peripherally injected morphine.