Pramipexole reduces inflammation in the experimental animal models of inflammation
Pramipexole reduces inflammation in the experimental animal models of inflammation
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DOI：
10.1080/08923973.2017.1284230
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Sadeghi, Hossein
中科院分区：
文献类型：
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作者：
Sadeghi, Heibatollah;Parishani, Mohammad;Sadeghi, Hossein
普拉克索是一种多巴胺（DA）受体激动剂（D2亚家族受体），广泛用于治疗帕金森病。一些流行病学和遗传学研究提出炎症在帕金森病的病理生理学中的作用。据我们所知，尚无关于普拉克索抗炎活性的研究。因此，本研究的目的是研究普拉克索的抗炎作用。在三种充分表征的炎症动物模型中研究了普拉克索的抗炎作用，包括角叉菜胶或福尔马林诱导的大鼠足炎症和12-O-十四酰佛波醇-13-乙酸酯（TPA）诱导的小鼠耳水肿。动物接受普拉克索（0.25、0.5和1 mg/kg，I. P.）角叉菜胶或福尔马林足底注射前30分钟。在对耳部小鼠局部施用TPA之前30分钟，还注射普拉克索（0.5和1 mg/kg）。在角叉菜胶试验中评价血清丙二醛（MDA）水平。最后，对炎症组织进行病理学检查。与对照组相比，普拉克索在角叉菜胶激发后1、2、3和4 h显著抑制足爪炎症（p
Pramipexole is a dopamine (DA) agonist (D2 subfamily receptors) that widely use in the treatment of Parkinson's diseases. Some epidemiological and genetic studies propose a role of inflammation in the pathophysiology of Parkinson's disease. To our knowledge, there is no study regarding the anti-inflammatory activity of pramipexol. Therefore, the aim of the study was to investigate antiinflammatory effect of pramipexol. Anti-inflammatory effects of pramipexole were studied in three well-characterized animal models of inflammation, including carrageenan-or formalin-induced paw inflammation in rats, and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. The animals received pramipexol (0.25, 0.5 and 1mg/kg, I.P.) 30 min before subplantar injection of carrageenan or formalin. Pramipexol (0.5 and 1 mg/kg) was also injected 30 min before topical application of TPA on the ear mice. Serum malondialdehyde (MDA) levels were evaluated in the carrageenan test. Finally, pathological examination of the inflamed tissues was carried out. Pramipexole significantly inhibited paw inflammation 1, 2, 3 and 4 h after carrageenan challenge compared with the control group (p